| Literature DB >> 12921947 |
Panagoula Kollia1, Maria Samara, Kostas Stamatopoulos, Chrysoula Belessi, Niki Stavroyianni, Aliki Tsompanakou, Anastasia Athanasiadou, Nikos Vamvakopoulos, Nikos Laoutaris, Achilles Anagnostopoulos, Athanasios Fassas.
Abstract
We examined transferrin receptor (TfR) 1 and TfR2 mRNA expression in 50 acute myeloid leukemia (AML) patients by RT-PCR, with primers specific for exons 15-17 (TfR1), 3-5 (TfR2-alpha) and 4-5 (TfR2-beta) of the corresponding gene. There were 4/50 TfR1-negative (-), 3/50 TfR2-alpha mRNA (-) and 13/50 TfR2-beta mRNA (-) cases; only three cases were TfR1/2 mRNA (-). No significant correlations were identified between TfR2-beta mRNA negativity and specific FAB subtypes, karyotype or attainment of complete remission. These findings suggest that: (i) TfR2 expression is not restricted to erythroid cells, and (ii) iron import proteins might complement each other in AML cells.Entities:
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Year: 2003 PMID： 12921947 DOI： 10.1016/s0145-2126(03)00100-0
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156