OBJECTIVE: To investigate the alternation and significance of CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of colorectal cancer patients. METHODS: The expression of CD4(+) T cells, CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of 60 colorectal cancer patients were detected with flow cytometry pre-operatively and 1, 3 months post-operatively, compared with those of 10 healthy persons. RESULTS: CD4(+) T cells expression of colorectal cancer patients was the same as the healthy persons. The proportion of CD4(+)CD45RO(+) T cells of colorectal cancer patients was higher, which descended post-operatively, especially in Dukes A and B patients, while CD4(+)CD45RA(+) T cells showed the opposite findings. CONCLUSION: CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells, playing an important immune effect in colorectal cancer patients, is closely related to stage and prognosis.
OBJECTIVE: To investigate the alternation and significance of CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of colorectal cancerpatients. METHODS: The expression of CD4(+) T cells, CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of 60 colorectal cancerpatients were detected with flow cytometry pre-operatively and 1, 3 months post-operatively, compared with those of 10 healthy persons. RESULTS:CD4(+) T cells expression of colorectal cancerpatients was the same as the healthy persons. The proportion of CD4(+)CD45RO(+) T cells of colorectal cancerpatients was higher, which descended post-operatively, especially in Dukes A and B patients, while CD4(+)CD45RA(+) T cells showed the opposite findings. CONCLUSION:CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells, playing an important immune effect in colorectal cancerpatients, is closely related to stage and prognosis.
Authors: Z Zhang; J Huang; C Zhang; H Yang; H Qiu; J Li; Y Liu; L Qin; L Wang; S Hao; F Zhang; X Wang; B Shan Journal: Cancer Gene Ther Date: 2015-02-27 Impact factor: 5.987