OBJECTIVE: To evaluate the applicability of Keith Edwards scoring system for the diagnosis of childhood tuberculosis. METHODS: One hundred and one children aged 2 months to 12 years who fulfilled the inclusion criteria were evaluated with Keith Edwards score. The diagnosis of tuberculosis by Keith Edwards score and the definitive reference were compared. RESULTS: Among the 65 children diagnosed as having tuberculosis by the definitive reference, 59 had a Keith Edwards score of >7. Four children had a score of >7 but were not suffering from tuberculosis. The sensitivity and specificity of this score have been found to be 91% and 88% respectively. CONCLUSION: In select population with indicative clinical features, Keith Edwards score can be a definitive guideline for the diagnosis of childhood tuberculosis. However, more studies are required for the validation of this clinical score before it can be used as a definitive diagnostic reference standard for tuberculosis.
OBJECTIVE: To evaluate the applicability of Keith Edwards scoring system for the diagnosis of childhood tuberculosis. METHODS: One hundred and one children aged 2 months to 12 years who fulfilled the inclusion criteria were evaluated with Keith Edwards score. The diagnosis of tuberculosis by Keith Edwards score and the definitive reference were compared. RESULTS: Among the 65 children diagnosed as having tuberculosis by the definitive reference, 59 had a Keith Edwards score of >7. Four children had a score of >7 but were not suffering from tuberculosis. The sensitivity and specificity of this score have been found to be 91% and 88% respectively. CONCLUSION: In select population with indicative clinical features, Keith Edwards score can be a definitive guideline for the diagnosis of childhood tuberculosis. However, more studies are required for the validation of this clinical score before it can be used as a definitive diagnostic reference standard for tuberculosis.
Authors: Leonardo Gil-Santana; Jilson L Almeida-Junior; Carolina A M Oliveira; Lucas S Hickson; Carla Daltro; Simone Castro; Hardy Kornfeld; Eduardo M Netto; Bruno B Andrade Journal: PLoS One Date: 2016-01-11 Impact factor: 3.240
Authors: Victor Francisco Gomes; Andreas Andersen; Grethe Lemvik; Christian Wejse; Ines Oliveira; Fina J Vieira; Luis José Carlos; Cesaltina da Silva Vieira; Peter Aaby; Per Gustafson Journal: BMJ Open Date: 2013-03-26 Impact factor: 2.692