Literature DB >> 12921230

Economics of suboptimal drug use: cost-savings of using JNC-recommended medications for management of uncomplicated essential hypertension.

K Tom Xu1, Michael Moloney, Sidney Phillips.   

Abstract

OBJECTIVES: To quantify potential cost-savings associated with better compliance with the guidelines of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure UNC V) and to determine whether suboptimal utilization of medications is associated with higher costs for other health services. STUDY
DESIGN: Secondary data analysis using the Medical Expenditure Panel Survey (MEPS) conducted by the Agency for Healthcare Research and Quality and the National Center for Health Statistics. A complex sampling design was used to provide nationally representative estimates.
METHODS: From interviews with a population-based and nationally representative sample of 22 601 individuals, 1588 patients with essential hypertension without other comorbid cardiovascular conditions were selected, representing 19.6 million patients in the United States in 1996. All medical treatments for essential hypertension in 1996 were extracted from the MEPS. Using the JNC V guidelines, prescriptions used in treating essential hypertension were categorized into first-line drugs (diuretics and beta-blockers), second-line drugs (calcium-channel blockers and angiotensin-converting enzyme inhibitors), and third-line (nonrecommended) drugs. Nonprescription expenditures were calculated. Multivariate analyses were performed to determine whether use of the first-line drugs was associated with cost-savings.
RESULTS: Compliance rate with the JNC guidelines was low. About 36%, 67%, and 87% of patients in the nation received first-, second-, and third-line drugs, respectively, at some point during 1996. Prescription expenditure constituted more than 67% of the total expenditures for treating essential hypertension. The use of first-line drugs (vs second-line drugs) was associated with expenditures that were dollar 2.6 billion to dollar 3.2 billion lower.
CONCLUSIONS: Compliance with the JNC guidelines for treating essential hypertension may reduce the costs of prescriptions and other medical services. Raising awareness of the JNC guidelines is crucial to achieve cost effectiveness in choosing treatment alternatives.

Entities:  

Mesh:

Substances:

Year:  2003        PMID: 12921230

Source DB:  PubMed          Journal:  Am J Manag Care        ISSN: 1088-0224            Impact factor:   2.229


  9 in total

Review 1.  Measuring adherence to practice guidelines for the management of hypertension: an evaluation of the literature.

Authors:  Jessica L Milchak; Barry L Carter; Paul A James; Gail Ardery
Journal:  Hypertension       Date:  2004-09-20       Impact factor: 10.190

2.  Outpatient antihypertensive drug utilization in Canton Sarajevo during five years period (2004-2008) and adherence to treatment guidelines assessment.

Authors:  Tarik Catić; Begler Begović
Journal:  Bosn J Basic Med Sci       Date:  2011-05       Impact factor: 3.363

3.  A cross-sectional evidence-based review of pharmaceutical promotional marketing brochures and their underlying studies: is what they tell us important and true?

Authors:  Roberto Cardarelli; John C Licciardone; Lockwood G Taylor
Journal:  BMC Fam Pract       Date:  2006-03-03       Impact factor: 2.497

4.  Explicit and implicit evaluation of physician adherence to hypertension guidelines.

Authors:  Gail Ardery; Barry L Carter; Jessica L Milchak; George R Bergus; Jeffrey D Dawson; Paul A James; Carrie Franciscus; Yoonsang Kim
Journal:  J Clin Hypertens (Greenwich)       Date:  2007-02       Impact factor: 3.738

5.  Economic analysis of a randomized trial of academic detailing interventions to improve use of antihypertensive medications.

Authors:  Steven R Simon; Hector P Rodriguez; Sumit R Majumdar; Ken Kleinman; Cheryl Warner; Susanne Salem-Schatz; Irina Miroshnik; Stephen B Soumerai; Lisa A Prosser
Journal:  J Clin Hypertens (Greenwich)       Date:  2007-01       Impact factor: 3.738

6.  Educating primary care clinicians about health disparities.

Authors:  Roberto Cardarelli; Ana L Chiapa
Journal:  Osteopath Med Prim Care       Date:  2007-02-01

7.  Economic evaluation for first-line anti-hypertensive medicines: applications for the Philippines.

Authors:  Lester Sam Araneta Geroy
Journal:  Cost Eff Resour Alloc       Date:  2012-12-10

8.  Antihypertensive medication prescription patterns and time trends for newly-diagnosed uncomplicated hypertension patients in Taiwan.

Authors:  Pang-Hsiang Liu; Jung-Der Wang
Journal:  BMC Health Serv Res       Date:  2008-06-18       Impact factor: 2.655

9.  Comorbidity Status and Annual Total Medical Expenditures in U.S. Hypertensive Adults.

Authors:  Chanhyun Park; Jing Fang; Nikki A Hawkins; Guijing Wang
Journal:  Am J Prev Med       Date:  2017-12       Impact factor: 5.043

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.