John O Willoughby1, Kenneth J Pope, Vaughn Eaton. 1. Centre for Neuroscience and Department of Medicine (Neurology) School of Informatics and Engineering Division of Pharmacy, Flinders University and Medical Centre, Adelaide, South Australia, Australia. John.@Willoughby@flinders.edu.au
Abstract
PURPOSE: To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy. METHODS: Open and double-blind trials of nicotine patches in an "n-of-one" study. The double-blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double-blind manner. RESULTS: In an open study, nicotine patches reduced seizures from 1.65 +/- 2.36 to 0.01 +/- 0.0 seizures per day (p < 0.0001). In a double-blinded placebo-controlled phase, the average frequency of seizures on nicotine versus placebo was 0 +/- 0 versus 0.56 +/- 1.14 seizures per day (p < 0.0001). CONCLUSIONS:Nicotine patches may be of benefit to some individuals with ADNFLE.
RCT Entities:
PURPOSE: To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy. METHODS: Open and double-blind trials of nicotine patches in an "n-of-one" study. The double-blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double-blind manner. RESULTS: In an open study, nicotine patches reduced seizures from 1.65 +/- 2.36 to 0.01 +/- 0.0 seizures per day (p < 0.0001). In a double-blinded placebo-controlled phase, the average frequency of seizures on nicotine versus placebo was 0 +/- 0 versus 0.56 +/- 1.14 seizures per day (p < 0.0001). CONCLUSIONS:Nicotine patches may be of benefit to some individuals with ADNFLE.
Authors: Jennifer L Dewolfe; Beth Malow; John Huguenard; Robert Stickgold; Blaise Bourgeois; Gregory L Holmes Journal: Epilepsy Curr Date: 2013-01 Impact factor: 7.500
Authors: Henry A Lester; Cheng Xiao; Rahul Srinivasan; Cagdas D Son; Julie Miwa; Rigo Pantoja; Matthew R Banghart; Dennis A Dougherty; Alison M Goate; Jen C Wang Journal: AAPS J Date: 2009-03-12 Impact factor: 4.009