| Literature DB >> 12916968 |
Michael T Crimmins1, Amy C DeBaillie.
Abstract
[reactiojn: see text] The enantioselective synthesis of (+)-rogioloxepane A has been achieved in 21 steps from 1,5-hexadien-3-ol. The key steps in the synthesis are an asymmetric glycolate alkylation leading to the diene 2 and a subsequent ring-closing metathesis to construct the oxepene core.Entities:
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Year: 2003 PMID： 12916968 DOI： 10.1021/ol034923l
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005