Literature DB >> 12916967

2'-modified-2-thiothymidine oligonucleotides.

Kallanthottathil G Rajeev1, Thazha P Prakash, Muthiah Manoharan.   

Abstract

[reaction: see text] Oligonucleotides with novel modifications, 2'-O-[2-(methoxy)ethyl]-2-thiothymidine and 2'-deoxy-2'-fluoro-2-thiothymidine, have been synthesized. These modified oligonucleotides exhibited very high thermal stability when hybridized with complementary RNA. 2-O-(2-Methoxy)ethyl-2-thiothymidine modified oligonucleotide phosphodiesters showed enhanced resistance toward nucleases (t(1/2) > 24 h), but 2'-deoxy-2'-fluoro-2-thiothymidine modified oligonucleotide phosphodiesters showed limited stability to nucleotytic degradation.

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Year:  2003        PMID： 12916967     DOI： 10.1021/ol0348607

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Metal-bipyridine complexes in DNA backbones and effects on thermal stability.

Authors:  Mildred M Rodriguez-Ramos; Jonathan J Wilker
Journal:  J Biol Inorg Chem       Date:  2010-02-26       Impact factor: 3.358

2.  Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.

Authors:  Andrei A Ivanov; Hyojin Ko; Liesbet Cosyn; Savitri Maddileti; Pedro Besada; Ingrid Fricks; Stefano Costanzi; T Kendall Harden; Serge Van Calenbergh; Kenneth A Jacobson
Journal:  J Med Chem       Date:  2007-02-16       Impact factor: 7.446

3.  Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.

Authors:  Benjamin Diop-Frimpong; Thazha P Prakash; Kallanthottathil G Rajeev; Muthiah Manoharan; Martin Egli
Journal:  Nucleic Acids Res       Date:  2005-09-16       Impact factor: 16.971

4.  Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine.

Authors:  Peter Haeberli; Imre Berger; Pradeep S Pallan; Martin Egli
Journal:  Nucleic Acids Res       Date:  2005-07-18       Impact factor: 16.971

5.  Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases.

Authors:  Vladimir A Stepchenko; Anatoly I Miroshnikov; Frank Seela; Igor A Mikhailopulo
Journal:  Beilstein J Org Chem       Date:  2016-12-01       Impact factor: 2.883

6.  Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes.

Authors:  Brooke A Anderson; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2016-03-30       Impact factor: 4.354
  6 in total

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