| Literature DB >> 12916912 |
Buchi N Nalluri1, K P R Chowdary, K V R Murthy, A R Hayman, G Becket.
Abstract
The objective of this work is physicochemical characterization of nimesulide-cyclodextrin binary systems both in solution and solid state and to improve the dissolution properties of nimesulide (N) via complexation with alpha-, beta, and gamma-cyclodextrins (CDs). Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1H nuclear magnetic resonance (1H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H-NMR studies in solution revealed 1:1 M complexation of N with all CDs. A true inclusion of N with beta-CD at 1:2 M in solid state was confirmed by DSC, powder X-RD and SEM studies. Dissolution properties of N-CD binary systems were superior when compared to pure N.Entities:
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Year: 2003 PMID： 12916912 PMCID： PMC2750298 DOI： 10.1208/pt040102
Source DB: PubMed Journal: AAPS PharmSciTech ISSN： 1530-9932 Impact factor: 3.246