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Literature DB >> 12916750

Measurement of dioxins in human blood: improvement of analytical method.

Abstract

We have improved the method of measuring dioxins in the blood of Yusho patients; with this improved method, it is possible to take measurements quickly and precisely, using as little as 5g of blood. The specific points of improvement of this method are the extraction of lipids from blood by accelerated solvent extractor (ASE), the miniaturization of column cleanup for the purification of dioxins, and the use of a solvent cut large volume (SCLV) injection system with high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Using this improved method of analysis, we are currently investigating dioxins in the blood of 400 Yusho patients collected in Japan in 2002. We here describe the details of our announcement at Dioxin 2002 Symposium about the improvement of this analysis method, and discuss several other modifications.

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Year: 2003 PMID： 12916750 DOI： 10.2486/indhealth.41.197

Source DB: PubMed Journal: Ind Health ISSN： 0019-8366 Impact factor: 2.179

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Cited

9 in total

Review 1. Ten years of progress in the Hokkaido birth cohort study on environment and children's health: cohort profile--updated 2013.

Authors: Reiko Kishi; Sachiko Kobayashi; Tamiko Ikeno; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Seiko Sasaki; Emiko Okada; Sumitaka Kobayashi; Ikuko Kashino; Kumiko Itoh; Sonomi Nakajima
Journal: Environ Health Prev Med Date: 2013-11 Impact factor: 3.674

2. Current state of yusho and prospects for therapeutic strategies.

Authors: Chikage Mitoma; Hiroshi Uchi; Kiyomi Tsukimori; Takashi Todaka; Jumboku Kajiwara; Takayuki Shimose; Manabu Akahane; Tomoaki Imamura; Masutaka Furue
Journal: Environ Sci Pollut Res Int Date: 2017-12-01 Impact factor: 4.223

3. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age.

Authors: Sonomi Nakajima; Yasuaki Saijo; Shizue Kato; Seiko Sasaki; Akiko Uno; Nobuo Kanagami; Hironori Hirakawa; Tsuguhide Hori; Kazuhiro Tobiishi; Takashi Todaka; Yuji Nakamura; Satoko Yanagiya; Yasuhito Sengoku; Takao Iida; Fumihiro Sata; Reiko Kishi
Journal: Environ Health Perspect Date: 2006-05 Impact factor: 9.031

4. Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident.

Authors: Kiyomi Tsukimori; Shoji Tokunaga; Satoko Shibata; Hiroshi Uchi; Daisuke Nakayama; Tadayuki Ishimaru; Hitoo Nakano; Norio Wake; Takesumi Yoshimura; Masutaka Furue
Journal: Environ Health Perspect Date: 2008-05 Impact factor: 9.031

9. Effect of colestimide on the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dizenzofurans, and polychlorinated biphenyls in blood of Yusho patients.

Authors: Takashi Todaka; Akinori Honda; Masami Imaji; Yoshiko Takao; Chikage Mitoma; Masutaka Furue
Journal: Environ Health Date: 2016-06-04 Impact factor: 5.984

9 in total

Measurement of dioxins in human blood: improvement of analytical method.

Review 1. Ten years of progress in the Hokkaido birth cohort study on environment and children's health: cohort profile--updated 2013.

2. Current state of yusho and prospects for therapeutic strategies.

3. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age.

4. Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident.

5. The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus.

6. Influence of dioxin-related compounds on physical function in Yusho incident victims.

Review 7. Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho.

Review 8. Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.

9. Effect of colestimide on the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dizenzofurans, and polychlorinated biphenyls in blood of Yusho patients.