D J Barker1. 1. MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.
Abstract
AIM: To elucidate the fetal origins of hypertension. METHODS: A systematic search was made for records of early growth, comprising measurements taken either at birth and/or during infancy, for groups of men and women now in middle-late life. Over 25,000 men and women born before 1931 were successfully traced. RESULTS: Retarded growth in fetal life was strongly related to high blood pressure in adult life. CONCLUSION: Hypertension is programmed by an adverse environment in utero. It is linked to impaired development in both early and late gestation.
AIM: To elucidate the fetal origins of hypertension. METHODS: A systematic search was made for records of early growth, comprising measurements taken either at birth and/or during infancy, for groups of men and women now in middle-late life. Over 25,000 men and women born before 1931 were successfully traced. RESULTS:Retarded growth in fetal life was strongly related to high blood pressure in adult life. CONCLUSION:Hypertension is programmed by an adverse environment in utero. It is linked to impaired development in both early and late gestation.
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