Literature DB >> 12916055

Synthesis and in vitro evaluation of the anticancer activity of novel fluorinated thiazolo[4, 5-d]pyrimidines.

Hesham T Y Fahmy1, Sherif A F Rostom, Manal N Saudi, Jordan K Zjawiony, David J Robins.   

Abstract

The synthesis of several thiazolo[4, 5-d]pyrimidines containing a fluorophenyl moiety substituted at different positions and through different bridges is described. Twenty new compounds were prepared and evaluated for their anticancer activity using the USA-NCI in-vitro screening program. Three compounds were found active and their anticancer activity against 60 human tumor cell lines are described in detail.

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Year:  2003        PMID： 12916055     DOI： 10.1002/ardp.200300734

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  6 in total

1.  Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents.

Authors:  Zhong-Hua Li; Xue-Qi Liu; Peng-Fei Geng; Jin-Lian Ma; Tao-Qian Zhao; Hao-Ming Wei; Bin Yu; Hong-Min Liu
Journal:  Medchemcomm       Date:  2017-06-22       Impact factor: 3.597

2.  p-TSA-promoted syntheses of 5H-benzo[h] thiazolo[2,3-b]quinazoline and indeno[1,2-d] thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma.

Authors:  Amit K Keshari; Ashok K Singh; Vinit Raj; Amit Rai; Prakruti Trivedi; Balaram Ghosh; Umesh Kumar; Atul Rawat; Dinesh Kumar; Sudipta Saha
Journal:  Drug Des Devel Ther       Date:  2017-05-29       Impact factor: 4.162

3.  Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides.

Authors:  Eman M Flefel; Wael A El-Sayed; Ashraf M Mohamed; Walaa I El-Sofany; Hanem M Awad
Journal:  Molecules       Date:  2017-01-20       Impact factor: 4.411

4.  Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators.

Authors:  Bhimanna Kuppast; Katerina Spyridaki; Christophina Lynch; Yueshan Hu; George Liapakis; Gareth E Davies; Hesham Fahmy
Journal:  Med Chem       Date:  2014       Impact factor: 2.745

5.  Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues.

Authors:  Ebtesam A Basiony; Allam A Hassan; Zahra M Al-Amshany; Ahmed A Abd-Rabou; Adel A-H Abdel-Rahman; Nasser A Hassan; Wael A El-Sayed
Journal:  Molecules       Date:  2020-01-18       Impact factor: 4.411

6.  Synthesis, Structural Characterization and Anticancer Activity of New 5-Trifluoromethyl-2-thioxo-thiazolo[4,5-d]pyrimidine Derivatives.

Authors:  Lilianna Becan; Anna Pyra; Nina Rembiałkowska; Iwona Bryndal
Journal:  Pharmaceuticals (Basel)       Date:  2022-01-13
  6 in total

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