| Literature DB >> 12915452 |
Proton Rahman1, Albert Jones, Joseph Curtis, Sylvia Bartlett, Lynette Peddle, Bridget A Fernandez, Nelson B Freimer.
Abstract
The population of the province of Newfoundland and Labrador is genetically isolated. This isolation is evidenced by an overabundance of several monogenic disorders. The Newfoundland population, like that of other isolates, is now the focus of interest for identification of genes implicated in common diseases. However, the utility of such populations for this purpose remains unproven. In this paper, we review the current genetic architecture of the province, with respect to geographic isolation, homogeneity, founder effect, genetic drift and extended linkage disequilibrium. Based on these factors, we propose that the population of Newfoundland offers many advantages for genetic mapping of common diseases, compared with admixed populations, and even compared with other isolates.Mesh：
Year: 2003 PMID： 12915452 DOI： 10.1093/hmg/ddg257
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150