| Literature DB >> 12915069 |
J Timothy Greenamyre1, Ranjita Betarbet, Todd B Sherer.
Abstract
Parkinson's disease (PD) is occasionally caused by single gene mutations or by single toxic exposures, but most cases of PD are probably caused by some combination of genetic susceptibility and environmental exposure. Using rotenone as a prototype for an environmental toxicant, we argue here that genetic and environmental causes of PD converge on common pathogenic mechanisms. If so, protective strategies devised for one type of PD may be broadly useful for other forms of the disease.Entities:
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Year: 2003 PMID： 12915069 DOI： 10.1016/s1353-8020(03)00023-3
Source DB: PubMed Journal: Parkinsonism Relat Disord ISSN： 1353-8020 Impact factor: 4.891