Literature DB >> 12914986

Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice.

M Imad Damaj1, Billy R Martin, Michael J Kuhar.   

Abstract

We investigated the effects of rat cocaine- and amphetamine-regulated transcript CART (55-102) after i.c.v. administration in mouse models of acute and persistent pain. CART was not active in the tail-flick or PPQ tests. It increased the latency to paw licking in the hot-plate test but only at doses that impaired motor function. CART produces antinociception in the formalin test in both phases. Our results suggest that CART is involved in supraspinal pain transmission.

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Year:  2003        PMID： 12914986     DOI： 10.1016/s0006-8993(03)03094-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Mitochondrial mechanism of neuroprotection by CART.

Authors:  Peizhong Mao; Ardi Ardeshiri; Rachel Jacks; Sufang Yang; Patricia D Hurn; Nabil J Alkayed
Journal:  Eur J Neurosci       Date:  2007-07-18       Impact factor: 3.386

Review 2.  CART peptides: regulators of body weight, reward and other functions.

Authors:  G Rogge; D Jones; G W Hubert; Y Lin; M J Kuhar
Journal:  Nat Rev Neurosci       Date:  2008-10       Impact factor: 34.870

Review 3.  Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets.

Authors:  Michael J Kuhar; Jason N Jaworski; George W Hubert; Kelly B Philpot; Geraldina Dominguez
Journal:  AAPS J       Date:  2005-09-02       Impact factor: 4.009

4.  Neuropeptidergic signaling partitions arousal behaviors in zebrafish.

Authors:  Ian G Woods; David Schoppik; Veronica J Shi; Steven Zimmerman; Haley A Coleman; Joel Greenwood; Edward R Soucy; Alexander F Schier
Journal:  J Neurosci       Date:  2014-02-26       Impact factor: 6.167

Review 5.  CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system.

Authors:  George W Hubert; Douglas C Jones; Mark C Moffett; George Rogge; Michael J Kuhar
Journal:  Biochem Pharmacol       Date:  2007-07-26       Impact factor: 5.858

6.  CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats.

Authors:  Zhiyuan Ma; Elliot Pearson; Rui Tao
Journal:  Neurosci Lett       Date:  2007-02-23       Impact factor: 3.046

7.  Assessing the neuronal serotonergic target-based antidepressant stratagem: impact of in vivo interaction studies and knockout models.

Authors:  R Rajkumar; R Mahesh
Journal:  Curr Neuropharmacol       Date:  2008-09       Impact factor: 7.363
  7 in total

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