Literature DB >> 12914720

Effects of growth hormone on lipid metabolism in humans.

Niels Møller1, Jakob Gjedsted, Lars Gormsen, Jens Fuglsang, Christian Djurhuus.   

Abstract

The most immediate effect of growth hormone (GH) administration in humans is a significant increase in free fatty acids after 1-2 h, reflecting stimulation of lipolysis and ketogenesis. This stimulation represents an important physiological adaptation to stress and fasting. When the capacity of GH to increase lipolysis is blocked, the protein-retaining and insulin-antagonistic effects of GH on glucose metabolism are either abolished or weakened dramatically, compatible with a key role for lipolysis in orchestrating the metabolic actions of GH.

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Year:  2003        PMID： 12914720     DOI： 10.1016/s1096-6374(03)00048-0

Source DB:  PubMed          Journal:  Growth Horm IGF Res        ISSN： 1096-6374            Impact factor:   2.372


  23 in total

1.  Subjects with isolated GH deficiency due to a null GHRHR mutation eat proportionally more, but healthier than controls.

Authors:  Alécia A Oliveira-Santos; Roberto Salvatori; Elenilde Gomes-Santos; João A M Santana; Ângela C G B Leal; Rita A A Barbosa; Carla R P Oliveira; Anita H O Souza; Eugênia H O Valença; Manuel H Aguiar-Oliveira
Journal:  Endocrine       Date:  2015-06-23       Impact factor: 3.633

2.  Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.

Authors:  Brandon C Sos; Charles Harris; Sarah M Nordstrom; Jennifer L Tran; Mercedesz Balázs; Patrick Caplazi; Maria Febbraio; Milana A B Applegate; Kay-Uwe Wagner; Ethan J Weiss
Journal:  J Clin Invest       Date:  2011-04       Impact factor: 14.808

3.  Alterations in neuronal transport but not blood-brain barrier transport are observed during gamma-hydroxybutyrate (GHB) sedative/hypnotic tolerance.

Authors:  Indranil Bhattacharya; Joseph J Raybon; Kathleen M K Boje
Journal:  Pharm Res       Date:  2006-08-10       Impact factor: 4.200

Review 4.  The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.

Authors:  Swapnil N Rajpathak; Marc J Gunter; Judith Wylie-Rosett; Gloria Y F Ho; Robert C Kaplan; Radhika Muzumdar; Thomas E Rohan; Howard D Strickler
Journal:  Diabetes Metab Res Rev       Date:  2009-01       Impact factor: 4.876

5.  The effect of rhGH on height velocity and BMI in children with CKD: a report of the NAPRTCS registry.

Authors:  Mouin G Seikaly; Pamela Waber; Bradley A Warady; Donald Stablein
Journal:  Pediatr Nephrol       Date:  2009-04-23       Impact factor: 3.714

6.  Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells.

Authors:  Hana Vakili; Yan Jin; Peter A Cattini
Journal:  J Biol Chem       Date:  2012-07-25       Impact factor: 5.157

7.  Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors.

Authors:  Ramamani Arumugam; Don Fleenor; Michael Freemark
Journal:  Endocrine       Date:  2007-11-02       Impact factor: 3.633

8.  OPPORTUNITY: a randomized clinical trial of growth hormone on outcome in hemodialysis patients.

Authors:  Joel D Kopple; Alfred K Cheung; Jens Sandahl Christiansen; Christian Born Djurhuus; Meguid El Nahas; Bo Feldt-Rasmussen; Martin Lange; William E Mitch; Christoph Wanner; Jonas Wiedemann; T Alp Ikizler
Journal:  Clin J Am Soc Nephrol       Date:  2008-11       Impact factor: 8.237

Review 9.  Growth hormone, IGF-I and insulin and their abuse in sport.

Authors:  R I G Holt; P H Sönksen
Journal:  Br J Pharmacol       Date:  2008-03-31       Impact factor: 8.739

10.  Management of type 2 diabetes mellitus associated with pituitary gigantism.

Authors:  Omar Ali; Swati Banerjee; Daniel F Kelly; Phillip D K Lee
Journal:  Pituitary       Date:  2007       Impact factor: 4.107
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