Literature DB >> 12914552

The pros and cons of noninferiority trials.

Stuart J Pocock1.   

Abstract

Noninferiority trials comparing new treatment with an active standard control are becoming increasingly common. This article discusses relevant issues regarding their need, design, analysis and interpretation: the appropriate choice of control group, types of noninferiority trial, ethical considerations, sample size determination and potential pitfalls to consider.

Mesh：

Substances：

Year:  2003        PMID： 12914552     DOI： 10.1046/j.1472-8206.2003.00162.x

Source DB:  PubMed          Journal:  Fundam Clin Pharmacol        ISSN： 0767-3981            Impact factor:   2.748


  28 in total

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Review 6.  Recommendations for improving the design, conduct, and analysis of clinical trials in hospital-acquired pneumonia and ventilator-associated pneumonia.

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8.  Evolution of psychopharmacology trial design and analysis: six decades in the making.

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10.  Performance of breast ultrasound computer-aided diagnosis: dependence on image selection.

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