BACKGROUND AND OBJECTIVES: Nd:YAG laser-induced thermo therapy (LITT) of rat brains is associated with blood-brain barrier (BBB) permeability changes. We address the question of whether LITT-induced locoregional disruption of the BBB could possibly allow a locoregional passage of chemotherapeutic agents into brain tissue to treat malignant glioma. STUDY DESIGN/ MATERIALS AND METHODS: CD Fischer rats were subject to LITT of the left forebrain. Disruption of the BBB was analyzed using Evans blue and immunohistochemistry (IH). Animals were perfused with paclitaxel, and high-pressure liquid chromatography (HPLC) was employed to analyze the content of paclitaxel in brain and plasma samples. RESULTS: LITT induces an opening of the BBB as demonstrated by locoregional extravasation of Evans blue, C3C, fibrinogen, and IgM. HPLC proved the passage of paclitaxel across the disrupted BBB. CONCLUSIONS: LITT induces a locoregional passage of chemotherapeutic agents into the brain tissue. This is of potential interest for the treatment of brain tumors. Copyright 2003 Wiley-Liss, Inc.
BACKGROUND AND OBJECTIVES: Nd:YAG laser-induced thermo therapy (LITT) of rat brains is associated with blood-brain barrier (BBB) permeability changes. We address the question of whether LITT-induced locoregional disruption of the BBB could possibly allow a locoregional passage of chemotherapeutic agents into brain tissue to treat malignant glioma. STUDY DESIGN/ MATERIALS AND METHODS: CD Fischer rats were subject to LITT of the left forebrain. Disruption of the BBB was analyzed using Evans blue and immunohistochemistry (IH). Animals were perfused with paclitaxel, and high-pressure liquid chromatography (HPLC) was employed to analyze the content of paclitaxel in brain and plasma samples. RESULTS:LITT induces an opening of the BBB as demonstrated by locoregional extravasation of Evans blue, C3C, fibrinogen, and IgM. HPLC proved the passage of paclitaxel across the disrupted BBB. CONCLUSIONS:LITT induces a locoregional passage of chemotherapeutic agents into the brain tissue. This is of potential interest for the treatment of brain tumors. Copyright 2003 Wiley-Liss, Inc.
Authors: Rami Abu Fanne; Taher Nassar; Sergei Yarovoi; Anwar Rayan; Itschak Lamensdorf; Michael Karakoveski; Polianski Vadim; Mahmud Jammal; Douglas B Cines; Abd Al-Roof Higazi Journal: Neuropharmacology Date: 2010-01-06 Impact factor: 5.250
Authors: Eric C Leuthardt; Chong Duan; Michael J Kim; Jian L Campian; Albert H Kim; Michelle M Miller-Thomas; Joshua S Shimony; David D Tran Journal: PLoS One Date: 2016-02-24 Impact factor: 3.240
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