PURPOSE: Patients with spinal cord injuries have abnormal seminal plasma, which contributes to impaired sperm motility and viability. A common finding in these patients is an elevated leukocyte count in semen. We examined the prostatic tissue of spinal cord injured patients vs young healthy controls to determine whether a pathological process related to the prostate gland is a possible source of leukocytospermia. MATERIALS AND METHODS: Seven men with a mean age of 26.1 years with spinal cord injury and 4 controls with a mean age of 35.0 years underwent standard transrectal ultrasound guided prostate biopsy. Semen analyses were performed prior to biopsies. At least 3 biopsy cores were obtained from each prostate and all underwent routine hematoxylin and eosin staining. RESULTS: No significant abnormalities were found in any prostate biopsy cores. Two spinal cord injured patients had minor evidence of prostatic inflammation in 1 core. No inflammation was seen in any control specimens. None of the specimens showed signs of malignancy. CONCLUSIONS: Prostate biopsies obtained in this study did not show any signs of a chronic or acute significant inflammatory process that could explain increased leukocytospermia seen in patients with spinal cord injury.
PURPOSE:Patients with spinal cord injuries have abnormal seminal plasma, which contributes to impaired sperm motility and viability. A common finding in these patients is an elevated leukocyte count in semen. We examined the prostatic tissue of spinal cord injured patients vs young healthy controls to determine whether a pathological process related to the prostate gland is a possible source of leukocytospermia. MATERIALS AND METHODS: Seven men with a mean age of 26.1 years with spinal cord injury and 4 controls with a mean age of 35.0 years underwent standard transrectal ultrasound guided prostate biopsy. Semen analyses were performed prior to biopsies. At least 3 biopsy cores were obtained from each prostate and all underwent routine hematoxylin and eosin staining. RESULTS: No significant abnormalities were found in any prostate biopsy cores. Two spinal cord injured patients had minor evidence of prostatic inflammation in 1 core. No inflammation was seen in any control specimens. None of the specimens showed signs of malignancy. CONCLUSIONS: Prostate biopsies obtained in this study did not show any signs of a chronic or acute significant inflammatory process that could explain increased leukocytospermia seen in patients with spinal cord injury.
Authors: Daniel Kagedan; Irene Lecker; Ihor Batruch; Christopher Smith; Ilia Kaploun; Kirk Lo; Ethan Grober; Eleftherios P Diamandis; Keith A Jarvi Journal: Clin Proteomics Date: 2012-02-06 Impact factor: 3.988
Authors: Barbara Ferreira da Silva; Chen Meng; Dominic Helm; Fiona Pachl; Jürgen Schiller; Emad Ibrahim; Charles M Lynne; Nancy L Brackett; Ricardo Pimenta Bertolla; Bernhard Kuster Journal: Mol Cell Proteomics Date: 2016-01-26 Impact factor: 5.911