PURPOSE: To evaluate the effect of blood glucose (BG) regulation on the retinal nerve fiber layer (RNFL) in diabetic patients by using a scanning laser polarimeter (NFA-GDx). METHODS: We prospectively assessed RNFL thickness in diabetic patients and an age-matched control group. Patients without diabetic retinopathy, with BG >250 mg/dl, HbA1c >8%, fructosamine >285 micromol/l and triglyceride >200 mg/dl were included in the study. RNFL assessment was performed before and after metabolic regulation of diabetes. Symmetry, superior maximum, ellipse modulation and the average thickness variables of NFA-GDx were used for the assessment. Mann-Whitney U and Wilcoxon tests were used for the statistical analysis. RESULTS: A total of 40 diabetic patients were included in the study and a repeat RNFL examination could be performed in 22 of them following regulation of BG levels. None of the GDx variables were significantly different between pre- and postregulation measurements (p > 0.05, Wilcoxon test). The mean superior maximum, ellipse modulation and average thickness values of the diabetic group were significantly lower than the control group (p < 0.05, Mann-Whitney U-test). CONCLUSIONS: Poor metabolic control of diabetes mellitus adversely affects the thickness of RNFL and this effect does not seem to be acute since it was not reversed by short-term BG regulation. This issue needs to be kept in mind when assessing glaucomatous progress in diabetic patients. Copyright 2003 S. Karger AG, Basel
PURPOSE: To evaluate the effect of blood glucose (BG) regulation on the retinal nerve fiber layer (RNFL) in diabeticpatients by using a scanning laser polarimeter (NFA-GDx). METHODS: We prospectively assessed RNFL thickness in diabeticpatients and an age-matched control group. Patients without diabetic retinopathy, with BG >250 mg/dl, HbA1c >8%, fructosamine >285 micromol/l and triglyceride >200 mg/dl were included in the study. RNFL assessment was performed before and after metabolic regulation of diabetes. Symmetry, superior maximum, ellipse modulation and the average thickness variables of NFA-GDx were used for the assessment. Mann-Whitney U and Wilcoxon tests were used for the statistical analysis. RESULTS: A total of 40 diabeticpatients were included in the study and a repeat RNFL examination could be performed in 22 of them following regulation of BG levels. None of the GDx variables were significantly different between pre- and postregulation measurements (p > 0.05, Wilcoxon test). The mean superior maximum, ellipse modulation and average thickness values of the diabetic group were significantly lower than the control group (p < 0.05, Mann-Whitney U-test). CONCLUSIONS: Poor metabolic control of diabetes mellitus adversely affects the thickness of RNFL and this effect does not seem to be acute since it was not reversed by short-term BG regulation. This issue needs to be kept in mind when assessing glaucomatous progress in diabeticpatients. Copyright 2003 S. Karger AG, Basel
Authors: Kevin W Bronson-Castain; Marcus A Bearse; Jessica Neuville; Soffia Jonasdottir; Barbara King-Hooper; Shirin Barez; Marilyn E Schneck; Anthony J Adams Journal: Retina Date: 2012-01 Impact factor: 4.256
Authors: Carine Biallosterski; Mirjam E J van Velthoven; Robert P J Michels; Reinier O Schlingemann; J Hans DeVries; Frank D Verbraak Journal: Br J Ophthalmol Date: 2007-03-23 Impact factor: 4.638
Authors: Kevin W Bronson-Castain; Marcus A Bearse; Jessica Neuville; Soffia Jonasdottir; Barbara King-Hooper; Shirin Barez; Marilyn E Schneck; Anthony J Adams Journal: Retina Date: 2009-05 Impact factor: 4.256
Authors: Euan N Paterson; Meera L Ravindran; Kayleigh Griffiths; Claire A Le Velly; Chris C Cardwell; Rachel V McCarter; Patrick Nicol; Jay K Chhablani; Mohammed Abdul Rasheed; Kiran Kumar Vupparaboina; Thomas J MacGillivray; Mark Harbinson; Alexander P Maxwell; Ruth E Hogg; Gareth J McKay Journal: BMC Nephrol Date: 2020-01-31 Impact factor: 2.388