Literature DB >> 12913306

Conjugated linoleic acid (CLA) inhibits fatty acid synthetase activity in vitro.

Hirosuke Oku1, Sawitree Wongtangtintharn, Hironori Iwasaki, Takayoshi Toda.   

Abstract

This paper describes the in vitro effect of conjugated linoleic acid (CLA) on fatty acid biosynthesis. Among the rat liver enzymes involved in fatty acid biosynthesis, fatty acid synthetase (FAS) showed the largest activity fluctuation with the types of fatty acids. Of the fatty acids, CLA was the most potent inhibitor of FAS, and the 9c, 11t-rather than the 10t, 12c-isomer showed greater inhibition. CLA also significantly lowered the incorporation of [14C]-acetate into phospholipid in breast cancer cells, supporting the view that CLA inhibits fatty acid biosynthesis through the interaction with FAS.

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Year:  2003        PMID： 12913306     DOI： 10.1271/bbb.67.1584

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

1.  Influence of dietary oil content and conjugated linoleic acid (CLA) on lipid metabolism enzyme activities and gene expression in tissues of Atlantic salmon (Salmo salar L.).

Authors:  Sean R Kennedy; Michael J Leaver; Patrick J Campbell; Xiaozhong Zheng; James R Dick; Douglas R Tocher
Journal:  Lipids       Date:  2006-05       Impact factor: 1.880

2.  trans-10,cis-12 conjugated linoleic acid improved growth performance, reduced lipid deposition and influenced CPT I kinetic constants of juvenile Synechogobius hasta.

Authors:  Xiao-Ying Tan; Zhi Luo; Qiang Zeng; Yan-Hong Zhao; Xu Liu
Journal:  Lipids       Date:  2013-01-16       Impact factor: 1.880

3.  Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.).

Authors:  Zhan-yu Zhao; Tian-xing Wu; Hong-gang Tang; Ji-ze Zhang
Journal:  J Zhejiang Univ Sci B       Date:  2008-09       Impact factor: 3.066

4.  Conjugated linoleic acid reduces hepatic steatosis, improves liver function, and favorably modifies lipid metabolism in obese insulin-resistant rats.

Authors:  Amy Noto; Peter Zahradka; Natalia Yurkova; Xueping Xie; Evan Nitschmann; Malcolm Ogborn; Carla G Taylor
Journal:  Lipids       Date:  2006-02       Impact factor: 1.880

Review 5.  Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered.

Authors:  William B Kinlaw; Paul W Baures; Leslie E Lupien; Wilson L Davis; Nancy B Kuemmerle
Journal:  J Cell Physiol       Date:  2016-02-16       Impact factor: 6.384

6.  Incorporation of branched-chain fatty acid into cellular lipids and caspase-independent apoptosis in human breast cancer cell line, SKBR-3.

Authors:  Sawitree Wongtangtintharn; Hirosuke Oku; Hironori Iwasaki; Masashi Inafuku; Takayoshi Toda; Teruyoshi Yanagita
Journal:  Lipids Health Dis       Date:  2005-11-23       Impact factor: 3.876

7.  The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes.

Authors:  Ana Camila Dos Santos Dias; Nicolas Ruiz; Aurélie Couzinet-Mossion; Samuel Bertrand; Muriel Duflos; Yves-François Pouchus; Gilles Barnathan; Hassan Nazih; Gaetane Wielgosz-Collin
Journal:  Mar Drugs       Date:  2015-08-06       Impact factor: 5.118
  7 in total

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