Literature DB >> 12913247

Insulinomimetic zinc(II) complexes with natural products: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus.

Yoshitane Kojima1, Yutaka Yoshikawa, Eriko Ueda, Rie Ueda, Shuhei Yamamoto, Katsumi Kumekawa, Naohisa Yanagihara, Hiromu Sakurai.   

Abstract

In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(-)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-A(y) mice with type 2 diabetes mellitus was observed by daily i.p. injections of a monomeric zinc(II) complex, Zn(qui)(2), for 13 d.

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Year:  2003        PMID： 12913247     DOI： 10.1248/cpb.51.1006

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

Review 1.  Zinc homeostasis in the metabolic syndrome and diabetes.

Authors:  Xiao Miao; Weixia Sun; Yaowen Fu; Lining Miao; Lu Cai
Journal:  Front Med       Date:  2013-02-06       Impact factor: 4.592

2.  A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes.

Authors:  Yusuke Adachi; Jiro Yoshida; Yukihiro Kodera; Akira Kato; Yutaka Yoshikawa; Yoshitane Kojima; Hiromu Sakurai
Journal:  J Biol Inorg Chem       Date:  2004-09-18       Impact factor: 3.358

3.  The influence of zinc supplementation on the pancreas of streptozotocin-diabetic rats.

Authors:  Sema Bolkent; Refiye Yanardag; Sehnaz Bolkent; Ozgur Mutlu
Journal:  Dig Dis Sci       Date:  2009-12       Impact factor: 3.199

Review 4.  Jasada bhasma, a Zinc-Based Ayurvedic Preparation: Contemporary Evidence of Antidiabetic Activity Inspires Development of a Nanomedicine.

Authors:  Rinku D Umrani; Kishore M Paknikar
Journal:  Evid Based Complement Alternat Med       Date:  2015-03-18       Impact factor: 2.629

Review 5.  Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review of Classical and New Compounds: Part-I.

Authors:  Raquel Vieira; Selma B Souto; Elena Sánchez-López; Ana López Machado; Patricia Severino; Sajan Jose; Antonello Santini; Ana Fortuna; Maria Luisa García; Amelia M Silva; Eliana B Souto
Journal:  Pharmaceuticals (Basel)       Date:  2019-10-10

6.  Alterations in somatostatin cells and biochemical parameters following zinc supplementation in gastrointestinal tissue of streptozotocin-induced diabetic rats.

Authors:  Sema Bolkent; Sehnaz Bolkent; Refiye Yanardag; Ozgur Mutlu; Sukriye Yildirim
Journal:  Acta Histochem Cytochem       Date:  2006-02-28       Impact factor: 1.938
  6 in total

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