Literature DB >> 12912874

New dogmas or old?

B J R Whittle1.   

Abstract

Recent experimental studies may undermine our understanding of the gastrointestinal side effects of non-steroidal anti-inflammatory drugs and cast a shadow on the original concept that underpins the development of the recent addition to the clinical anti-inflammatory armamentarium, the COX-2 selective inhibitors. But is this just a passing cloud or a total eclipse of the COX theory?

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Year:  2003        PMID： 12912874      PMCID： PMC1773776          DOI： 10.1136/gut.52.9.1379

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  29 in total

1.  Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs?

Authors:  Peter Jüni; Anne W S Rutjes; Paul A Dieppe
Journal:  BMJ       Date:  2002-06-01

Review 2.  The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis.

Authors:  S Somasundaram; H Hayllar; S Rafi; J M Wrigglesworth; A J Macpherson; I Bjarnason
Journal:  Scand J Gastroenterol       Date:  1995-04       Impact factor: 2.423

3.  Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa.

Authors:  B J Whittle; G A Higgs; K E Eakins; S Moncada; J R Vane
Journal:  Nature       Date:  1980-03-20       Impact factor: 49.962

4.  COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin.

Authors:  G Sigthorsson; R Crane; T Simon; M Hoover; H Quan; J Bolognese; I Bjarnason
Journal:  Gut       Date:  2000-10       Impact factor: 23.059

5.  NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.

Authors:  J L Wallace; W McKnight; B K Reuter; N Vergnolle
Journal:  Gastroenterology       Date:  2000-09       Impact factor: 22.682

6.  Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation.

Authors:  B K Reuter; N M Davies; J L Wallace
Journal:  Gastroenterology       Date:  1997-01       Impact factor: 22.682

7.  Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study.

Authors:  A Anthony; A P Dhillon; C Thrasivoulou; R E Pounder; A J Wakefield
Journal:  Aliment Pharmacol Ther       Date:  1995-12       Impact factor: 8.171

8.  Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Authors:  J L Masferrer; B S Zweifel; P T Manning; S D Hauser; K M Leahy; W G Smith; P C Isakson; K Seibert
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

9.  Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin.

Authors:  B J Whittle; F László; S M Evans; S Moncada
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

10.  Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.

Authors:  B J Whittle
Journal:  Gastroenterology       Date:  1981-01       Impact factor: 22.682
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  1 in total

1.  Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions.

Authors:  Manfred Stolte; Diana Karimi; Michael Vieth; Hildegard Volkholz; Klaus Dirschmid; Sigrid Rappel; Birgit Bethke
Journal:  World J Gastroenterol       Date:  2005-10-07       Impact factor: 5.742
  1 in total

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