Literature DB >> 1290460

Cytotoxicity of human beta-interferon produced in human glioma cells transfected with its gene by means of liposomes.

J Yoshida1, M Mizuno, K Yagi.   

Abstract

The cytotoxicity of human beta-interferon (HuIFN-beta) produced in human glioma cells was examined by use of our liposomes entrapping two plasmids, pSV2neo and pSVMTV-IFN-beta. After the cells had been transfected with these genes by means of the liposomes, neomycin-resistant cells were selected. When the selected cells were subjected to a single exposure to dexamethasone, all of the cells were found to produce HuIFN-beta and were eliminated by 8 days. Accordingly, the effect of HuIFN-beta produced in human glioma cells is considered to be cytocidal.

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Year:  1992        PMID： 1290460

Source DB:  PubMed          Journal:  Biochem Int        ISSN： 0158-5231


  6 in total

1.  Apoptotic DNA endonuclease (DNase-gamma) gene transfer induces cell death accompanying DNA fragmentation in human glioma cells.

Authors:  Ryuta Saito; Masaaki Mizuno; Toshihiro Kumabe; Takashi Yoshimoto; Sei-ichi Tanuma; Jun Yoshida
Journal:  J Neurooncol       Date:  2003-05       Impact factor: 4.130

2.  Enhancement of cytokine expression in transiently transfected cells by magnetoliposome mediated hyperthermia.

Authors:  I A Bouhon; M Shinkai; H Honda; T Kobayashi
Journal:  Cytotechnology       Date:  1997-11       Impact factor: 2.058

3.  Interferon-beta inhibits proliferation and progression through S phase of the cell cycle in five glioma cell lines.

Authors:  J I Garrison; M E Berens; J R Shapiro; S Treasurywala; G Floyd-Smith
Journal:  J Neurooncol       Date:  1996-12       Impact factor: 4.130

Review 4.  Clinical gene therapy for brain tumors. Liposomal delivery of anticancer molecule to glioma.

Authors:  Jun Yoshida; Masaaki Mizuno
Journal:  J Neurooncol       Date:  2003-12       Impact factor: 4.130

5.  Long-term follow-up results of 175 patients with malignant glioma: importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation.

Authors:  J Yoshida; Y Kajita; T Wakabayashi; K Sugita
Journal:  Acta Neurochir (Wien)       Date:  1994       Impact factor: 2.216

6.  Tumor necrosis factor-alpha gene transfer augments anti-Fas antibody-mediated apoptosis in human glioma cells.

Authors:  M Mizuno; J Yoshida
Journal:  Jpn J Cancer Res       Date:  1996-05
  6 in total

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