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Literature DB >> 12904022

A concise route to benzofused macrolactones via ynolides: cycloproparadicicol.

Abstract

A new facile synthesis has been developed for nanomolar Hsp90 inhibitor, cycloproparadicicol (2). Our approach relied on cobalt-complexation promoted RCM, in combination with tandem Diels-Alder/retro-Diels-Alder reactions to assemble the resorcycinylic macrolactone.

Entities: Chemical Gene

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Year: 2003 PMID： 12904022 DOI： 10.1021/ja036192q

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

5 in total

1. Introduction of the (-)-berkelic acid side chain and assignment of the C-22 stereochemistry.

Authors: Xiaoxing Wu; Jingye Zhou; Barry B Snider
Journal: J Org Chem Date: 2009-08-21 Impact factor: 4.354

2. Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the "Meta Constraint" in the Palladium/Norbornene Catalysis.

Authors: Jianchun Wang; Yun Zhou; Xiaolong Xu; Peng Liu; Guangbin Dong
Journal: J Am Chem Soc Date: 2020-01-30 Impact factor: 15.419

A concise route to benzofused macrolactones via ynolides: cycloproparadicicol.

1. Introduction of the (-)-berkelic acid side chain and assignment of the C-22 stereochemistry.

2. Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the "Meta Constraint" in the Palladium/Norbornene Catalysis.

Review 3. Natural and Synthetic Lactones Possessing Antitumor Activities.

4. Fragmentation of bicyclic γ-silyloxy-β-hydroxy-α-diazolactones as an approach to ynolides.

5. Nematicidal resorcylides from the aquatic fungus Caryospora callicarpa YMF1.01026.