| Literature DB >> 1290221 |
O A Pliasunova, I N Egoricheva, N V Fediuk, A G Pokrovskiĭ, L A Baltina, Iu I Murinov, G A Tolstikov.
Abstract
The anti-HIV activity of beta-glycyrrhizic acid (GA) and various derivatives was studied using various strains of HIV-1 and HIV-2 in primary infected lymphoblastoid cells MT-4 and monocyte cell line U-973 chronically infected with HIV-1 and containing provirus (GKV 4005). Beta-glycyrrhizic acid and its derivatives were shown to effectively inhibit HIV-1 reproduction in MT-4 cells. The antiviral effect of beta-GA sodium salt exceeded that of AZT in cells GKV 4005. The selective indices for some GA salts were evaluated, namely: 53 for 1NH4 salt of GA, 6.7 for 1K-2Li salt of GA; 4.45 for GA. The mechanism of GA action is discussed.Entities:
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Year: 1992 PMID： 1290221
Source DB: PubMed Journal: Vopr Virusol ISSN： 0507-4088