Literature DB >> 12901941

Differentiation therapy.

Alexander I Spira1, Michael A Carducci.   

Abstract

Differentiation therapy is an area of oncology that is in its infancy. Theoretically, the concept of differentiation therapy involves turning a cancer cell "off" biologically and reverting to a more "benign" phenotype. Many agents have been studied over the past few years, with many already either in use clinically or showing future promise.

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Year:  2003        PMID： 12901941     DOI： 10.1016/s1471-4892(03)00081-x

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  31 in total

1.  Blocking p55PIK signaling inhibits proliferation and induces differentiation of leukemia cells.

Authors:  G Wang; Y Deng; X Cao; S Lai; Y Tong; X Luo; Y Feng; X Xia; J Gong; J Hu
Journal:  Cell Death Differ       Date:  2012-06-22       Impact factor: 15.828

Review 2.  p53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignancies.

Authors:  Yogen Saunthararajah; Pierre Triozzi; Brian Rini; Arun Singh; Tomas Radivoyevitch; Mikkael Sekeres; Anjali Advani; Ramon Tiu; Frederic Reu; Matt Kalaycio; Ed Copelan; Eric Hsi; Alan Lichtin; Brian Bolwell
Journal:  Semin Oncol       Date:  2012-02       Impact factor: 4.929

Review 3.  Cancer stem cells and cancer therapy.

Authors:  Sara Soltanian; Maryam M Matin
Journal:  Tumour Biol       Date:  2011-02-12

4.  Differentiation-inducing activity of hydroxycamptothecin on cancer stem-like cells derived from hepatocellular carcinoma.

Authors:  Yi Zhang; Wen-Jie Song; Fu-Qin Zhang; Wei-Hui Liu; Ke-Feng Dou
Journal:  Dig Dis Sci       Date:  2011-02-12       Impact factor: 3.199

5.  Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics.

Authors:  Ernesto Burgio; Lucia Migliore
Journal:  Mol Biol Rep       Date:  2015-04       Impact factor: 2.316

Review 6.  Cancer stem cells and hepatocellular carcinoma.

Authors:  Zhixing Yao; Lopa Mishra
Journal:  Cancer Biol Ther       Date:  2009-09       Impact factor: 4.742

7.  Notch signaling activation suppresses v-Src-induced transformation of neural cells by restoring TGF-β-mediated differentiation.

Authors:  Samira Amarir; Maria Marx; Georges Calothy
Journal:  PLoS One       Date:  2010-10-22       Impact factor: 3.240

8.  Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.

Authors:  Veronika V Borutinskaite; Karl-Eric Magnusson; Ruta Navakauskiene
Journal:  Mol Biol Rep       Date:  2012-09-26       Impact factor: 2.316

9.  Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors.

Authors:  Jing Zhang; Jonathan S Harrison; Milan Uskokovic; Michael Danilenko; George P Studzinski
Journal:  Hematol Oncol       Date:  2010-09       Impact factor: 5.271

10.  Principles of cancer therapy: oncogene and non-oncogene addiction.

Authors:  Ji Luo; Nicole L Solimini; Stephen J Elledge
Journal:  Cell       Date:  2009-03-06       Impact factor: 41.582
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