| Literature DB >> 12901923 |
Jie Jack Li1, Kenneth G Carson, Bharat K Trivedi, Wen Song Yue, Qing Ye, Roberta A Glynn, Steven R Miller, David T Connor, Bruce D Roth, Jay R Luly, Joseph E Low, David J Heilig, Weixing Yang, Shixin Qin, Stephen Hunt.
Abstract
Interleukin-8 modulation is implicated in many inflammatory and cancer diseases. Starting from a mass-screening hit, the synthesis and structure-activity relationship of 2-amino-3-heteroarylquinoxalines as non-peptide, small molecule interleukine-8 receptor antagonists have been developed. The optimized derivatives, PD 0210293 (13y) and PD 0220245 (13r), show inhibition of both IL-8 receptor binding and IL-8-mediated neutrophil chemotaxis.Entities:
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Year: 2003 PMID： 12901923 DOI： 10.1016/s0968-0896(03)00399-7
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641