Literature DB >> 12901908

Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.

Yoshio Saito1, Vanessa Escuret, David Durantel, Fabien Zoulim, Raymond F Schinazi, Luigi A Agrofoglio.   

Abstract

The synthesis of carbocyclic and phosphonocarbocyclic analogues of ribavirin, an anti-HCV inhibitor, are described. Those compounds were evaluated against HCV but also against other important viruses in order to determine their spectrum of antiviral activity. Compounds 6 and 13 displayed a moderate IC(50) against HIV-1 of 43.8 and 37 microM, respectively.

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Year:  2003        PMID： 12901908     DOI： 10.1016/s0968-0896(03)00349-3

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  11 in total

1.  3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.

Authors:  Jay Lin; Vincent Roy; Liya Wang; Li You; Luigi A Agrofoglio; Dominique Deville-Bonne; Tamara R McBrayer; Steven J Coats; Raymond F Schinazi; Staffan Eriksson
Journal:  Bioorg Med Chem       Date:  2010-03-15       Impact factor: 3.641

2.  Preparation of ribavirin analogues by copper- and ruthenium-catalyzed azide-alkyne 1,3-dipolar cycloaddition.

Authors:  Ugo Pradere; Vincent Roy; Tamara R McBrayer; Raymond F Schinazi; Luigi A Agrofoglio
Journal:  Tetrahedron       Date:  2008-07-05       Impact factor: 2.457

3.  Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis.

Authors:  Hui-Juan Cui; Xiao-Lin Tong; Ping Li; Ying-Xu Hao; Xiao-Guang Chen; Ai-Guo Li; Zhi-Yuan Zhang; Jun Duan; Min Zhen; Bin Zhang; Chuan-Jin Hua; Yue-Wen Gong
Journal:  World J Gastroenterol       Date:  2004-06-01       Impact factor: 5.742

4.  Design, synthesis, anticancer activity and docking studies of theophylline containing 1,2,3-triazoles with variant amide derivatives.

Authors:  Radhakrishnam Raju Ruddarraju; Adharvana Chari Murugulla; Ravindar Kotla; Muni Chandra Babu Tirumalasetty; Rajendra Wudayagiri; Shobha Donthabakthuni; Ravichandar Maroju
Journal:  Medchemcomm       Date:  2016-10-28       Impact factor: 3.597

5.  Design, synthesis, antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione system.

Authors:  Emilia Bankowska; Jan Balzarini; Iwona E Głowacka; Andrzej E Wróblewski
Journal:  Monatsh Chem       Date:  2014-01-25       Impact factor: 1.451

6.  Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues.

Authors:  Iwona E Głowacka; Jan Balzarini; Graciela Andrei; Robert Snoeck; Dominique Schols; Dorota G Piotrowska
Journal:  Bioorg Med Chem       Date:  2014-05-20       Impact factor: 3.641

7.  Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates.

Authors:  Abdelaaziz Ouahrouch; Moha Taourirte; Dominique Schols; Robert Snoeck; Graciela Andrei; Joachim W Engels; Hassan B Lazrek
Journal:  Arch Pharm (Weinheim)       Date:  2015-11-17       Impact factor: 3.751

Review 8.  Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.

Authors:  Tim Efthymiou; Wei Gong; Jean-Paul Desaulniers
Journal:  Molecules       Date:  2012-10-26       Impact factor: 4.411

9.  Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication.

Authors:  Zhao-Hong Li; Chien-Ming Li; Pin Ling; Fang-Hsiu Shen; Shih-Heng Chen; Ching-Chuan Liu; Chun-Keung Yu; Shun-Hua Chen
Journal:  J Infect Dis       Date:  2008-03-15       Impact factor: 5.226

10.  The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker.

Authors:  Iwona E Głowacka; Jan Balzarini; Andrzej E Wróblewski
Journal:  Eur J Med Chem       Date:  2013-10-30       Impact factor: 6.514
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