| Literature DB >> 12901570 |
Atze T Das1, Xue Zhou, Monique Vink, Bep Klaver, Ben Berkhout.
Abstract
To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a conditional live virus, of which the replication can be switched on and off at will, as a novel approach for an HIV vaccine.Entities:
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Year: 2002 PMID： 12901570 DOI： 10.1586/14760584.1.3.293
Source DB: PubMed Journal: Expert Rev Vaccines ISSN： 1476-0584 Impact factor: 5.217