What information is needed to design effective vaccination against intracellular pathogens causing chronic disease?

An appreciation of global features of immune regulation may lead to vaccination strategies effective in a genetically diverse population against a number of intracellular pathogens that cause chronic disease. Such global strategies appear more straightforward than strategies requiring a detailed knowledge of the specificity of 'protective T-cells'. Global strategies may be effective against the virus, bacteria and protozoa that respectively cause AIDS, tuberculosis and the leishmaniases.