Literature DB >> 12901435

Novel poly(ethylene glycol) derivatives with carboxylic acid pendant groups: synthesis and their protection and enhancing effect on non-viral gene transfection systems.

Yoshiyuki Koyama1, Tomoko Ito, Hidetoshi Matsumoto, Akihiko Tanioka, Tatsuya Okuda, Nobuaki Yamaura, Haruhiko Aoyagi, Takuro Niidome.   

Abstract

Novel carboxylic acid pendant-containing poly(ethylene glycol) (PEG) derivatives (PEG-Cs) were synthesized by the chemical modification of the carbon-carbon double-bond side chain of copoly(allyl glycidyl ether/ethylene oxide) (copoly(AGE/EO)). PEG-C showed a protecting ability for the DNA/polycation complex from the albumin-induced aggregation. It also expressed the enhanced efficiency on the polycation-mediated gene transfection on the cultured cells (up to 3-4-times higher), probably due to its disperse-stabilizing property and also the proton-sponge effect.

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Year:  2003        PMID： 12901435     DOI： 10.1163/15685620360674227

Source DB:  PubMed          Journal:  J Biomater Sci Polym Ed        ISSN： 0920-5063            Impact factor:   3.517


  9 in total

1.  Patterned PLG substrates for localized DNA delivery and directed neurite extension.

Authors:  Tiffany Houchin-Ray; Laura A Swift; Jae-Hyung Jang; Lonnie D Shea
Journal:  Biomaterials       Date:  2007-02-09       Impact factor: 12.479

2.  Loosening of DNA/polycation complexes by synthetic polyampholyte to improve the transcription efficiency: effect of charge balance in the polyampholyte.

Authors:  Chieko Yoshihara; Chwen-Yang Shew; Tomoko Ito; Yoshiyuki Koyama
Journal:  Biophys J       Date:  2010-04-07       Impact factor: 4.033

3.  Reactivity ratios, and mechanistic insight for anionic ring-opening copolymerization of epoxides.

Authors:  Bongjae F Lee; Martin Wolffs; Kris T Delaney; Johannes K Sprafke; Frank A Leibfarth; Craig J Hawker; Nathaniel A Lynd
Journal:  Macromolecules       Date:  2012-04-17       Impact factor: 5.985

4.  Preparation of DNA/Gold Nanoparticle Encapsulated in Calcium Phosphate.

Authors:  Tomoko Ito; Koyuki Ibe; Tomohiro Uchino; Hiroyuki Ohshima; Makoto Otsuka
Journal:  J Drug Deliv       Date:  2011-06-07

5.  Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus.

Authors:  Qin Zeng; Jianfeng Han; Dong Zhao; Tao Gong; Zhirong Zhang; Xun Sun
Journal:  Int J Nanomedicine       Date:  2012-02-27

6.  Targeting the EGF receptor for ovarian cancer therapy.

Authors:  Reema Zeineldin; Carolyn Y Muller; M Sharon Stack; Laurie G Hudson
Journal:  J Oncol       Date:  2009-12-28       Impact factor: 4.375

7.  A convenient and adjustable surface-modified complex containing poly-L-glutamic acid conjugates as a vector for gene delivery.

Authors:  Ye Sun; Yuzhao Tang; Maoquan Chu; Shuxian Song; Yanfei Xin
Journal:  Int J Nanomedicine       Date:  2008

8.  Highly Effective Non-Viral Antitumor Gene Therapy System Comprised of Biocompatible Small Plasmid Complex Particles Consisting of pDNA, Anionic Polysaccharide, and Fully Deprotected Linear Polyethylenimine.

Authors:  Yoshiyuki Koyama; Kikuya Sugiura; Chieko Yoshihara; Toshio Inaba; Tomoko Ito
Journal:  Pharmaceutics       Date:  2015-07-23       Impact factor: 6.321

9.  Efficient gene delivery system mediated by cis-aconitate-modified chitosan-g-stearic acid micelles.

Authors:  Jing-Jing Yao; Yong-Zhong Du; Hong Yuan; Jian You; Fu-Qiang Hu
Journal:  Int J Nanomedicine       Date:  2014-06-18
  9 in total

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