Y Zhao1, G X Qiu. 1. Department of Orthopedic Surgery, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. zhaoyupumch@hotmail.com
Abstract
OBJECTIVE: To determine the relationship between angiogenesis and vascular endothelial growth factor (VEGF) expression in osteosarcoma. METHODS: The expression of VEGF was evaluated by immunohistochemical staining of tumor specimens from 33 patients with osteosarcoma. The microvessel density was assessed by immunostaining with CD34 in the most neovascularized area (hot spots). RESULTS: In osteosarcoma, the mean microvessel count of VEGF strong-expression tumors was significantly higher than that of VEGF low-expression tumors (Wilcoxon rank sum test, P < 0.05). The close correlation was found between VEGF expression and microvessel density. In contrast, no association was found between Price's grade of osteosarcoma and VEGF expression, as well as microvessel density. CONCLUSION: These observations suggest that VEGF is an important angiogenic factor in osteosarcoma.
OBJECTIVE: To determine the relationship between angiogenesis and vascular endothelial growth factor (VEGF) expression in osteosarcoma. METHODS: The expression of VEGF was evaluated by immunohistochemical staining of tumor specimens from 33 patients with osteosarcoma. The microvessel density was assessed by immunostaining with CD34 in the most neovascularized area (hot spots). RESULTS: In osteosarcoma, the mean microvessel count of VEGF strong-expression tumors was significantly higher than that of VEGF low-expression tumors (Wilcoxon rank sum test, P < 0.05). The close correlation was found between VEGF expression and microvessel density. In contrast, no association was found between Price's grade of osteosarcoma and VEGF expression, as well as microvessel density. CONCLUSION: These observations suggest that VEGF is an important angiogenic factor in osteosarcoma.
Authors: Xia Li; Li Feng Liu; Yang Zhou Liu; Yu Tao Pan; Guang Li; Qing You Lu; Zeng Chun Li Journal: Balkan Med J Date: 2018-01-24 Impact factor: 2.021