BACKGROUND: Ofloxacin is a quinolone administered to patients with severe infections. Pharmacokinetic data on ofloxacin in critically ill patients on renal replacement therapy are sparse and conflicting. METHODS: Eight patients with anuric acute renal failure were administered 400 mg of ofloxacin intravenously. The pharmacokinetics of ofloxacin was analyzed during continuous venovenous hemofiltration (CVVH) with a high-flux polysulfone membrane. Serum and ultrafiltrate levels of ofloxacin were measured by means of high-performance liquid chromatography. RESULTS: Mean serum ofloxacin concentration peak was 5.5 +/- 0.7 mg/L. Elimination half-life, hemofiltration clearance, and total removal were 2.8 +/- 0.5 hours, 89.9 +/- 4.5 mL/min, and 76.9% +/- 7.1%, respectively. CONCLUSION: Ofloxacin is significantly and rapidly eliminated by CVVH with a high-flux polysulfone membrane.
BACKGROUND:Ofloxacin is a quinolone administered to patients with severe infections. Pharmacokinetic data on ofloxacin in critically ill patients on renal replacement therapy are sparse and conflicting. METHODS: Eight patients with anuric acute renal failure were administered 400 mg of ofloxacin intravenously. The pharmacokinetics of ofloxacin was analyzed during continuous venovenous hemofiltration (CVVH) with a high-flux polysulfone membrane. Serum and ultrafiltrate levels of ofloxacin were measured by means of high-performance liquid chromatography. RESULTS: Mean serum ofloxacin concentration peak was 5.5 +/- 0.7 mg/L. Elimination half-life, hemofiltration clearance, and total removal were 2.8 +/- 0.5 hours, 89.9 +/- 4.5 mL/min, and 76.9% +/- 7.1%, respectively. CONCLUSION:Ofloxacin is significantly and rapidly eliminated by CVVH with a high-flux polysulfone membrane.
Authors: Dominique Breilh; Patrick M Honore; David De Bels; Jason A Roberts; Jean Baptiste Gordien; Catherine Fleureau; Antoine Dewitte; Julien Coquin; Hadrien Rozé; Paul Perez; Rachid Attou; Sebastien Redant; Luc Kugener; Marie-Claude Saux; Herbert D Spapen; Alexandre Ouattara; Olivier Joannes-Boyau Journal: J Transl Int Med Date: 2019-12-31