BACKGROUND/AIMS: To determine whether preoperative natural killer (NK) cell activity has any prognostic significance in colon cancer patients. METHODS: The study population consisted of 140 patients with colon cancer. NK cell activity was determined within 2 weeks before surgery in 128 patients and at the time of diagnosis in the remaining 12 patients who either did not undergo surgery or who underwent palliative surgery only. Disease progression and postoperative prognosis were examined in relation to NK cell activity. RESULTS: Decreases in NK cell activity did not necessarily correspond to tumor stage. In curatively operated stage I-III diseases, preoperative NK cell activity of 20% or less correlated with poor survival. Lower activity was also associated with metachronous distant metastases but not with local recurrences. In particular, more than half the stage III patients with attenuated NK cell activity developed metastases. Multivariate analysis indicated that attenuated NK cell activity was a significant parameter for predicting distant metastasis following curative surgery for colon cancer. CONCLUSION: Preoperative NK cell activity has a significant prognostic value in curatively operated colon cancer, particularly for the development of metachronous distant metastasis in stage III patients. Copyright 2003 S. Karger AG, Basel
BACKGROUND/AIMS: To determine whether preoperative natural killer (NK) cell activity has any prognostic significance in colon cancerpatients. METHODS: The study population consisted of 140 patients with colon cancer. NK cell activity was determined within 2 weeks before surgery in 128 patients and at the time of diagnosis in the remaining 12 patients who either did not undergo surgery or who underwent palliative surgery only. Disease progression and postoperative prognosis were examined in relation to NK cell activity. RESULTS: Decreases in NK cell activity did not necessarily correspond to tumor stage. In curatively operated stage I-III diseases, preoperative NK cell activity of 20% or less correlated with poor survival. Lower activity was also associated with metachronous distant metastases but not with local recurrences. In particular, more than half the stage III patients with attenuated NK cell activity developed metastases. Multivariate analysis indicated that attenuated NK cell activity was a significant parameter for predicting distant metastasis following curative surgery for colon cancer. CONCLUSION: Preoperative NK cell activity has a significant prognostic value in curatively operated colon cancer, particularly for the development of metachronous distant metastasis in stage III patients. Copyright 2003 S. Karger AG, Basel
Authors: Stefan Stangl; Mathias Gehrmann; Julia Riegger; Kristin Kuhs; Isabelle Riederer; Wolfgang Sievert; Kathrin Hube; Ralph Mocikat; Ralf Dressel; Elisabeth Kremmer; Alan G Pockley; Lars Friedrich; Laszlo Vigh; Arne Skerra; Gabriele Multhoff Journal: Proc Natl Acad Sci U S A Date: 2010-12-27 Impact factor: 11.205
Authors: William P Accomando; John K Wiencke; E Andres Houseman; Rondi A Butler; Shichun Zheng; Heather H Nelson; Karl T Kelsey Journal: Clin Cancer Res Date: 2012-09-26 Impact factor: 12.531
Authors: Natalia Lapteva; April G Durett; Jiali Sun; Lisa A Rollins; Leslie L Huye; Jian Fang; Varada Dandekar; Zhuyong Mei; Kimberley Jackson; Juan Vera; Jun Ando; Minhtran C Ngo; Elaine Coustan-Smith; Dario Campana; Susann Szmania; Tarun Garg; Amberly Moreno-Bost; Frits Vanrhee; Adrian P Gee; Cliona M Rooney Journal: Cytotherapy Date: 2012-08-17 Impact factor: 5.414