Literature DB >> 1290020

The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence.

E R Holme1, J Veitch, A Johnston, I C McKay, K Whaley.   

Abstract

C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum albumin (BSA) ICs, or with the prevention of immune precipitation of BSA or alkaline phosphatase ICs, nor with immune adherence assayed using thyroglobulin and BSA ICs.

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Year:  1992        PMID： 1290020     DOI： 10.1007/bf00302150

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  25 in total

Review 1.  The molecular genetics of components of complement.

Authors:  R D Campbell; M C Carroll; R R Porter
Journal:  Adv Immunol       Date:  1986       Impact factor: 3.543

Review 2.  Inherited deficiency of the fourth component of human complement.

Authors:  G Hauptmann; G Tappeiner; J A Schifferli
Journal:  Immunodefic Rev       Date:  1988

3.  Covalent binding properties of the C4A and C4B isotypes of the fourth component of human complement on several C1-bearing cell surfaces.

Authors:  D E Isenman; J R Young
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

4.  Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

Authors:  M C Carroll; D M Fathallah; L Bergamaschini; E M Alicot; D E Isenman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

5.  The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals.

Authors:  A Fyfe; E R Holme; I C McKay; A Zoma; J Hunter; N P Lucie; K Whaley
Journal:  Clin Exp Immunol       Date:  1987-10       Impact factor: 4.330

6.  Primate erythrocyte-immune complex-clearing mechanism.

Authors:  J B Cornacoff; L A Hebert; W L Smead; M E VanAman; D J Birmingham; F J Waxman
Journal:  J Clin Invest       Date:  1983-02       Impact factor: 14.808

7.  The fluid-phase binding of human C4 and its genetic variants, C4A3 and C4B1, to immunoglobulins.

Authors:  N Kishore; D Shah; V M Skanes; R P Levine
Journal:  Mol Immunol       Date:  1988-09       Impact factor: 4.407

8.  The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

Authors:  D E Isenman; J R Young
Journal:  J Immunol       Date:  1984-06       Impact factor: 5.422

9.  Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups.

Authors:  H Dunckley; P A Gatenby; B Hawkins; S Naito; S W Serjeantson
Journal:  J Immunogenet       Date:  1987 Aug-Oct

10.  Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

Authors:  A H Fielder; M J Walport; J R Batchelor; R I Rynes; C M Black; I A Dodi; G R Hughes
Journal:  Br Med J (Clin Res Ed)       Date:  1983-02-05
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