Literature DB >> 12900169

Potential roles of insulin and IGF-1 in Alzheimer's disease.

Laura Gasparini1, Huaxi Xu.   

Abstract

Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.

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Year:  2003        PMID： 12900169     DOI： 10.1016/S0166-2236(03)00163-2

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  75 in total

1.  Foxo/atrogin induction in human and experimental myositis.

Authors:  Han-Kyu Lee; Edward Rocnik; Qinghao Fu; Bumsup Kwon; Ling Zeng; Kenneth Walsh; Henry Querfurth
Journal:  Neurobiol Dis       Date:  2012-05       Impact factor: 5.996

2.  Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic.

Authors:  Geert Jan Biessels; Aafke Koffeman; Philip Scheltens
Journal:  J Neurol       Date:  2005-11-14       Impact factor: 4.849

3.  POTENTIAL NON-GROWTH USES OF rhIGF-I.

Authors:  Roy J Kim; Adda Grimberg
Journal:  Growth Genet Horm       Date:  2007-03

4.  Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits.

Authors:  Jogender Mehla; Balwantsinh C Chauhan; Neelima B Chauhan
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

5.  Actions of β-amyloid protein on human neurons are expressed through the amylin receptor.

Authors:  Jack H Jhamandas; Zongming Li; David Westaway; Jing Yang; Simran Jassar; David MacTavish
Journal:  Am J Pathol       Date:  2010-12-23       Impact factor: 4.307

Review 6.  Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

Authors:  Sónia C Correia; Renato X Santos; George Perry; Xiongwei Zhu; Paula I Moreira; Mark A Smith
Journal:  Ageing Res Rev       Date:  2011-01-22       Impact factor: 10.895

7.  Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

Authors:  Yaomin Chen; Kun Zhou; Ruishan Wang; Yun Liu; Young-Don Kwak; Tao Ma; Robert C Thompson; Yongbo Zhao; Layton Smith; Laura Gasparini; Zhijun Luo; Huaxi Xu; Francesca-Fang Liao
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-23       Impact factor: 11.205

8.  Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.

Authors:  Ehud Cohen; Johan F Paulsson; Pablo Blinder; Tal Burstyn-Cohen; Deguo Du; Gabriela Estepa; Anthony Adame; Hang M Pham; Martin Holzenberger; Jeffery W Kelly; Eliezer Masliah; Andrew Dillin
Journal:  Cell       Date:  2009-12-11       Impact factor: 41.582

Review 9.  Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer's disease pathology.

Authors:  Thomas Arendt; Jens Stieler; Max Holzer
Journal:  J Neural Transm (Vienna)       Date:  2014-12-06       Impact factor: 3.575

10.  Predictors of progression of cognitive decline in Alzheimer's disease: the role of vascular and sociodemographic factors.

Authors:  Massimo Musicco; Katie Palmer; Giovanna Salamone; Federica Lupo; Roberta Perri; Serena Mosti; Gianfranco Spalletta; Fulvia di Iulio; Carla Pettenati; Luca Cravello; Carlo Caltagirone
Journal:  J Neurol       Date:  2009-04-08       Impact factor: 4.849
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