Literature DB >> 12900165

Numb and Numblike control cell number during vertebrate neurogenesis.

Jane E Johnson1.   

Abstract

A fundamental problem in nervous system development is how to control progenitor-cell divisions to generate the correct number of cells for the mature brain and spinal cord. A recent report by Petersen and colleagues has identified an essential role for Numb and a related protein, Numblike, in this process. This study demonstrates that Numb and Numblike function to maintain the self-renewal properties of neural progenitor cells in the vertebrate neural tube.

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Year:  2003        PMID： 12900165     DOI： 10.1016/S0166-2236(03)00166-8

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  13 in total

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