Literature DB >> 12899576

Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin.

Gregory M Glenn1, Richard T Kenney, Larry R Ellingsworth, Sarah A Frech, Scott A Hammond, J Paul Zoeteweij.   

Abstract

The skin is an attractive target for vaccine delivery. Topical application of adjuvants results in potent immune responses and good safety profiles. Adjuvants can be coadministered in a patch with vaccine antigens (transcutaneous immunization) or similar delivery format, or administered separately with an injection or IS patch (Iomai), leading to enhanced immune responses. These observations have moved into the clinic, highlighting the likelihood that skin delivery of vaccines will play an important future role in vaccine applications.

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Year:  2003        PMID： 12899576     DOI： 10.1586/14760584.2.2.253

Source DB:  PubMed          Journal:  Expert Rev Vaccines        ISSN： 1476-0584            Impact factor:   5.217


  37 in total

1.  Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells.

Authors:  Igor M Belyakov; Scott A Hammond; Jeffrey D Ahlers; Gregory M Glenn; Jay A Berzofsky
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808

2.  DNA vaccination in the skin using microneedles improves protection against influenza.

Authors:  Jae-Min Song; Yeu-Chun Kim; Eunju O; Richard W Compans; Mark R Prausnitz; Sang-Moo Kang
Journal:  Mol Ther       Date:  2012-04-17       Impact factor: 11.454

3.  Transcutaneous DNA immunization following waxing-based hair depilation elicits both humoral and cellular immune responses.

Authors:  Gang Xiao; Xinran Li; Amit Kumar; Zhengrong Cui
Journal:  Eur J Pharm Biopharm       Date:  2012-07-03       Impact factor: 5.571

4.  Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization.

Authors:  Yukai He; Jiying Zhang; Cara Donahue; Louis D Falo
Journal:  Immunity       Date:  2006-05       Impact factor: 31.745

5.  Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization.

Authors:  Mikayel Mkrtichyan; Anahit Ghochikyan; Nina Movsesyan; Adrine Karapetyan; Gayane Begoyan; Jianmei Yu; Gregory M Glenn; Ted M Ross; Michael G Agadjanyan; David H Cribbs
Journal:  DNA Cell Biol       Date:  2008-01       Impact factor: 3.311

Review 6.  Cutaneous immunization: an evolving paradigm in influenza vaccines.

Authors:  Harvinder S Gill; Sang-Moo Kang; Fu-Shi Quan; Richard W Compans
Journal:  Expert Opin Drug Deliv       Date:  2014-02-12       Impact factor: 6.648

Review 7.  New routes for allergen immunotherapy.

Authors:  Pål Johansen; Seraina von Moos; Deepa Mohanan; Thomas M Kündig; Gabriela Senti
Journal:  Hum Vaccin Immunother       Date:  2012-10-01       Impact factor: 3.452

8.  Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination.

Authors:  Yanpu He; Celestine Hong; Jiahe Li; MayLin T Howard; Yingzhong Li; Michelle E Turvey; Divakara S S M Uppu; John R Martin; Ketian Zhang; Darrell J Irvine; Paula T Hammond
Journal:  ACS Nano       Date:  2018-10-04       Impact factor: 15.881

9.  An electrically active microneedle array for electroporation.

Authors:  Seong-O Choi; Yeu Chun Kim; Jung-Hwan Park; Joshua Hutcheson; Harvinder S Gill; Yong-Kyu Yoon; Mark R Prausnitz; Mark G Allen
Journal:  Biomed Microdevices       Date:  2010-04       Impact factor: 2.838

10.  Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node.

Authors:  Joseph M Thompson; Michael G Nicholson; Alan C Whitmore; Melodie Zamora; Ande West; Akiko Iwasaki; Herman F Staats; Robert E Johnston
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422
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