Literature DB >> 12899517

A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.

Rajiv Kumar1, Mark R Pittelkow, Jeffrey L Salisbury, Joseph P Grande, Hee-Jeong Im, Kathrin A Feldmann, David Schilling.   

Abstract

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

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Year:  2003        PMID： 12899517      PMCID： PMC2903742          DOI： 10.1007/978-3-642-55580-0_8

Source DB:  PubMed          Journal:  Recent Results Cancer Res        ISSN： 0080-0015


  72 in total

1.  IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes.

Authors:  D Schilling; M R Pittelkow; R Kumar
Journal:  Oncogene       Date:  2001-11-29       Impact factor: 9.867

2.  Perturbation of renal amino acid transport by brush border membrane vesicles in the vitamin D-deficient rat.

Authors:  S Dabbagh; N Gusowski; M Padilla; M Theissen; R W Chesney
Journal:  Biochem Med Metab Biol       Date:  1990-08

3.  Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery.

Authors:  S S Jensen; M W Madsen; J Lukas; L Binderup; J Bartek
Journal:  Mol Endocrinol       Date:  2001-08

4.  Induced differentiation of U937 cells by 1,25-dihydroxyvitamin D3 involves cell cycle arrest in G1 that is preceded by a transient proliferative burst and an increase in cyclin expression.

Authors:  N Y Rots; A Iavarone; V Bromleigh; L P Freedman
Journal:  Blood       Date:  1999-04-15       Impact factor: 22.113

5.  Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cells.

Authors:  H Schäfer; P Lettau; A Trauzold; M Banasch; W E Schmidt
Journal:  Pancreas       Date:  1999-05       Impact factor: 3.327

6.  Calcitriol controls the epithelial calcium channel in kidney.

Authors:  Joost G J Hoenderop; Dominik Müller; Annemiete W C M VAN DER Kemp; Anita Hartog; Makoto Suzuki; Kenichi Ishibashi; Masashi Imai; Fred Sweep; Peter H G M Willems; Carel H VAN Os; René J M Bindels
Journal:  J Am Soc Nephrol       Date:  2001-07       Impact factor: 10.121

Review 7.  Clinical uses for calciotropic hormones 1,25-dihydroxyvitamin D3 and parathyroid hormone-related peptide in dermatology: a new perspective.

Authors:  M F Holick; M L Chen; X F Kong; D K Sanan
Journal:  J Investig Dermatol Symp Proc       Date:  1996-04

Review 8.  Treatment of psoriasis with calcipotriol and other vitamin D analogues.

Authors:  K Kragballe
Journal:  J Am Acad Dermatol       Date:  1992-12       Impact factor: 11.527

9.  25-hydroxycholecalciferol stimulation of muscle metabolism.

Authors:  S J Birge; J G Haddad
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

10.  1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.

Authors:  R J Wood; L Tchack; S Taparia
Journal:  BMC Physiol       Date:  2001-08-17
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  8 in total

1.  Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression.

Authors:  Oleg E Akilov; Mei X Wu; Irina V Ustyugova; Louis D Falo; Larisa J Geskin
Journal:  Exp Dermatol       Date:  2012-04       Impact factor: 3.960

2.  Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes.

Authors:  David P Steensma; Jessemy D Neiger; Julie C Porcher; J Jonathan Keats; P Leif Bergsagel; Thomas R Dennis; Ryan A Knudson; Robert B Jenkins; Rafael Santana-Davila; Rajiv Kumar; Rhett P Ketterling
Journal:  Cancer Res       Date:  2009-09-22       Impact factor: 12.701

3.  Immediate early gene X-1 interacts with proteins that modulate apoptosis.

Authors:  Rajiv Kumar; Ward Lutz; Elena Frank; Hee-Jeong Im
Journal:  Biochem Biophys Res Commun       Date:  2004-10-29       Impact factor: 3.575

Review 4.  Immediate early response gene X-1, a potential prognostic biomarker in cancers.

Authors:  Mei X Wu; Irina V Ustyugova; Liping Han; Oleg E Akilov
Journal:  Expert Opin Ther Targets       Date:  2013-02-04       Impact factor: 6.902

5.  1α,25-Dihydroxyvitamin D3 Encapsulated in Nanoparticles Prevents Venous Neointimal Hyperplasia and Stenosis in Porcine Arteriovenous Fistulas.

Authors:  Avishek K Singh; Chuanqi Cai; Sreenivasulu Kilari; Chenglei Zhao; Michael L Simeon; Edwin Takahashi; Elazer R Edelman; Hyunjoon Joon Kong; Thanila Macedo; Ravinder J Singh; Matthew W Urban; Rajiv Kumar; Sanjay Misra
Journal:  J Am Soc Nephrol       Date:  2021-02-24       Impact factor: 10.121

6.  Adventitial delivery of nanoparticles encapsulated with 1α, 25-dihydroxyvitamin D3 attenuates restenosis in a murine angioplasty model.

Authors:  Chuanqi Cai; Sreenivasulu Kilari; Chenglei Zhao; Avishek K Singh; Michael L Simeon; Avanish Misra; Yiqing Li; Edwin Takahashi; Rajiv Kumar; Sanjay Misra
Journal:  Sci Rep       Date:  2021-02-26       Impact factor: 4.379

7.  The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.

Authors:  Akshaar Brahmbhatt; Evelyn NievesTorres; Binxia Yang; William D Edwards; Prabir Roy Chaudhury; Min Kyun Lee; Hyunjoon Kong; Debabrata Mukhopadhyay; Rajiv Kumar; Sanjay Misra
Journal:  PLoS One       Date:  2014-07-18       Impact factor: 3.240

Review 8.  HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation.

Authors:  Nicole L Diggins; Meaghan H Hancock
Journal:  Noncoding RNA       Date:  2018-10-22
  8 in total

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