| Literature DB >> 12898429 |
Hector Montenegro, Marcelino Gutiérrez, Luz I Romero, Eduardo Ortega-Barría, Todd L Capson, Luis Cubilla Rios.
Abstract
Fractionation of Guatteria amplifolia yielded the alkaloids xylopine (1), nornuciferine (4), lysicamine (6), and laudanosine (5). Fractionation of Guatteria dumetorum yielded the alkaloids cryptodorine (2) and nornantenine (3). Compounds 1-4 demonstrated significant activity against Leishmania mexicana and L. panamensis. Xylopine (1) was among the most active compounds (LD 50 = 3 microM) and showed a 37-fold higher toxicity towards L. mexicana than macrophages, the regular host cells of Leishmania spp.Entities:
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Year: 2003 PMID： 12898429 DOI： 10.1055/s-2003-41126
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352