| Literature DB >> 12898419 |
Guo-Yu Pan1, Zhi-Jiang Huang, Guang-Ji Wang, J Paul Fawcett, Xiao-Dong Liu, Xiao-Chen Zhao, Jian-Guo Sun, Yuan-Yuan Xie.
Abstract
The mechanism of action of berberine as an antihyperglycaemic agent was investigated in the Caco-2 cell line. Berberine was found to effectively inhibit the activity of disaccharidases in Caco-2 cells. It also decreased sucrase activity after preincubation with Caco-2 cells for 72 hours. However gluconeogenesis and glucose consumption of Caco-2 cells were not influenced. 2-Deoxyglucose transporting through Caco-2 cell monolayers was decreased by berberine but the effect was not statistically significant. These results suggest that the antihyperglycaemic activity of berberine is at least partly due to its ability to inhibit alpha-glucosidase and decrease glucose transport through the intestinal epithelium.Entities:
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Year: 2003 PMID： 12898419 DOI： 10.1055/s-2003-41121
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352