Literature DB >> 1289816

Sequence specific block of in vitro DNA synthesis with isopropyl phosphotriesters in template oligodeoxyribonucleotides.

T Yashiki1, K Yamana, K Nunota, K Negishi.   

Abstract

We have synthesized four oligodeoxyribonucleotides each bearing an isopropyl phosphotriester at a defined position. These oligomers were used as templates for in vitro DNA synthesis catalyzed by Escherichia coli DNA polymerase I large fragment. Results showed that the phosphotriester inhibits the DNA chain elongation and the level of the inhibition is dependent on the base 5' to the phosphotriester.

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Year:  1992        PMID： 1289816

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN： 0261-3166


  5 in total

1.  DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

Authors:  Avvaru N Suhasini; Joshua A Sommers; Stephen Yu; Yuliang Wu; Ting Xu; Zvi Kelman; Daniel L Kaplan; Robert M Brosh
Journal:  J Biol Chem       Date:  2012-04-12       Impact factor: 5.157

2.  Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Authors:  Bin Ma; Adam T Zarth; Erik S Carlson; Peter W Villalta; Irina Stepanov; Stephen S Hecht
Journal:  Mutagenesis       Date:  2017-12-31       Impact factor: 3.000

3.  Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Authors:  Bin Ma; Adam T Zarth; Erik S Carlson; Peter W Villalta; Pramod Upadhyaya; Irina Stepanov; Stephen S Hecht
Journal:  Carcinogenesis       Date:  2018-02-09       Impact factor: 4.944

4.  Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Authors:  Bin Ma; Peter W Villalta; Adam T Zarth; Delshanee Kotandeniya; Pramod Upadhyaya; Irina Stepanov; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2015-10-12       Impact factor: 3.739

5.  Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Authors:  Bin Ma; Adam T Zarth; Erik S Carlson; Peter W Villalta; Pramod Upadhyaya; Irina Stepanov; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2017-11-30       Impact factor: 3.739
  5 in total

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