Literature DB >> 1289806

A study on conformationally restricted sangivamycins and their inhibitory abilities of protein kinases.

T Iimori1, Y Murai, T Sugiyama, H Shiroto, T Ishizaki, Y Wakizaka, Y Kodama, S Ohuchi, Y Ohtsuka, T Oishi.   

Abstract

Conformational restrictions of sangivamycin, a rather selective inhibitor of PKC, could be achieved by the use of the steric effect and the gauche effect of the substituents on the ribofuranose moiety. The conformational deviations obtained by these methods were found to nicely correlate with the inhibitory ability of PKC.

Entities:  

Mesh:

Substances:

Year:  1992        PMID: 1289806

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN: 0261-3166


  1 in total

1.  Sangivamycin and its derivatives inhibit Haspin-Histone H3-survivin signaling and induce pancreatic cancer cell death.

Authors:  Ligia I Bastea; Laeticia M A Hollant; Heike R Döppler; Elizabeth M Reid; Peter Storz
Journal:  Sci Rep       Date:  2019-11-12       Impact factor: 4.379

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.