Literature DB >> 12897640

Waiting for ON: a major problem in patients with Parkinson disease and ON/OFF motor fluctuations.

Doron Merims1, Ruth Djaldetti, Eldad Melamed.   

Abstract

The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations: time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.

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Year:  2003        PMID： 12897640     DOI： 10.1097/00002826-200307000-00009

Source DB:  PubMed          Journal:  Clin Neuropharmacol        ISSN： 0362-5664            Impact factor:   1.592


  7 in total

Review 1.  Soluble and controlled-release preparations of levodopa: do we really need them?

Authors:  Giovanni Fabbrini; Flavio Di Stasio; Maria Bloise; Alfredo Berardelli
Journal:  J Neurol       Date:  2010-11       Impact factor: 4.849

2.  Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson's Disease.

Authors:  Stuart Isaacson; Mark Lew; William Ondo; Jean Hubble; Thomas Clinch; Fernando Pagan
Journal:  Mov Disord Clin Pract       Date:  2016-05-25

3.  A randomized, double-blind, placebo-controlled trial of camicinal in Parkinson's disease.

Authors:  Sarah L Marrinan; Tal Otiker; Lakshmi S Vasist; Rachel A Gibson; Bhopinder K Sarai; Matthew E Barton; Duncan B Richards; Per M Hellström; Dag Nyholm; George E Dukes; David J Burn
Journal:  Mov Disord       Date:  2017-12-26       Impact factor: 10.338

Review 4.  Management of dysphagia and gastroparesis in Parkinson's disease in real-world clinical practice - Balancing pharmacological and non-pharmacological approaches.

Authors:  Roongroj Bhidayasiri; Warongporn Phuenpathom; Ai Huey Tan; Valentina Leta; Saisamorn Phumphid; K Ray Chaudhuri; Pramod Kumar Pal
Journal:  Front Aging Neurosci       Date:  2022-08-11       Impact factor: 5.702

Review 5.  Should "on-demand" treatments for Parkinson's disease OFF episodes be used earlier?

Authors:  Stuart H Isaacson; Fernando L Pagan; Mark F Lew; Rajesh Pahwa
Journal:  Clin Park Relat Disord       Date:  2022-08-12

Review 6.  Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update.

Authors:  Dag Nyholm
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 5.577

7.  Onset and duration of effect of extended-release carbidopa-levodopa in advanced Parkinson's disease.

Authors:  Robert A Hauser; Aaron Ellenbogen; Sarita Khanna; Suneel Gupta; Nishit B Modi
Journal:  Neuropsychiatr Dis Treat       Date:  2018-03-22       Impact factor: 2.570
  7 in total

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