| Literature DB >> 12896820 |
Shigeru Saito1, Masatoshi Sakai.
Abstract
The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system allowing the second physiological trophoblastic invasion. In this review, we discuss that Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation.Entities:
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Year: 2003 PMID: 12896820 DOI: 10.1016/s0165-0378(03)00045-7
Source DB: PubMed Journal: J Reprod Immunol ISSN: 0165-0378 Impact factor: 4.054