Literature DB >> 12895087

Early amidation approach to 3-[(4-amido)pyrrol-2-yl]-2-indolinones.

Jerad M Manley1, Monica J Kalman, Brian G Conway, Cynthia C Ball, Jeffrey L Havens, Rajappa Vaidyanathan.   

Abstract

A new synthesis of 3-[(4-amido)pyrrol-2-yl]-2-indolinones has been developed, where the amide side chain was installed prior to pyrrole formation. This strategy precludes the need to use any coupling reagents to install the amide side chain. This process includes a zinc-free alternative to the Knorr pyrrole synthesis.

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Year:  2003        PMID： 12895087     DOI： 10.1021/jo034304q

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

Review 1.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

2.  Solution-phase synthesis of a tricyclic pyrrole-2-carboxamide discovery library applying a stetter-Paal-Knorr reaction sequence.

Authors:  Stefan Werner; Pravin S Iyer; Matthew D Fodor; Claire M Coleman; Leslie A Twining; Branko Mitasev; Kay M Brummond
Journal:  J Comb Chem       Date:  2006 May-Jun

3.  Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease.

Authors:  Hormoz Pourtaher; Alireza Hasaninejad; Aida Iraji
Journal:  Sci Rep       Date:  2022-09-08       Impact factor: 4.996

4.  Facile Syntheses and Molecular-Docking of Novel Substituted 3,4-Dimethyl-1H-pyrrole-2-carboxamide/carbohydrazide Analogues with Antimicrobial and Antifungal Properties.

Authors:  Jitendra D Bhosale; Rajesh Dabur; Gopal P Jadhav; R S Bendre
Journal:  Molecules       Date:  2018-04-11       Impact factor: 4.411
  4 in total

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