| Literature DB >> 12894996 |
Yumiko Tsuji1, Sumiko Denda, Tsutomu Soma, Laurel Raftery, Takashi Momoi, Toshihiko Hibino.
Abstract
TGF-beta plays important roles in the induction of catagen during the hair cycle. We examined whether TGF-beta2 could activate a caspase in human hair follicles. Using active caspase-9 and -3 specific antibodies, we found that TGF-beta2 activated these caspases in two regions, the lower part of the hair bulb and the outer layer of the outer root sheath. In addition, we searched for a plant extract that can effectively suppress TGF-beta action. We found that an extract of Hydrangea macrophylla reduced synthesis of a TGDbeta-inducible protein. We confirmed that the extract has a potential to promote hair elongation in the organ culture system. Furthermore, it delayed in vivo progression of catagen in a mouse model. Our results suggest that the induction of catagen by TGF-beta is mediated via activation of caspases and that a suppressor of TGF-beta could be effective in preventing male pattern baldness.Entities:
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Year: 2003 PMID： 12894996 DOI： 10.1046/j.1523-1747.2003.12173.x
Source DB: PubMed Journal: J Investig Dermatol Symp Proc ISSN： 1087-0024