Literature DB >> 12894170

Why do worms need cholesterol?

Teymuras V Kurzchalia1, Samuel Ward.   

Abstract

Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to have a major role in membrane structure. Instead, its most probable signalling functions are to control molting and induce a specialized non-feeding larval stage, although no cholesterol-derived signalling molecule has yet been identified for these or any other functions.

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Year:  2003        PMID: 12894170     DOI: 10.1038/ncb0803-684

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN: 1465-7392            Impact factor:   28.824


  62 in total

1.  The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.

Authors:  Takuji Yoshiyama-Yanagawa; Sora Enya; Yuko Shimada-Niwa; Shunsuke Yaguchi; Yoshikazu Haramoto; Takeshi Matsuya; Kensuke Shiomi; Yasunori Sasakura; Shuji Takahashi; Makoto Asashima; Hiroshi Kataoka; Ryusuke Niwa
Journal:  J Biol Chem       Date:  2011-06-01       Impact factor: 5.157

2.  The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.

Authors:  Anastasia P Grigorenko; Yuri K Moliaka; Martha C Soto; Craig C Mello; Evgeny I Rogaev
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-06       Impact factor: 11.205

3.  Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics.

Authors:  Mohamad Firas Bassissi; Michel Alvinerie; Pascal Guy Pierre Martin; Bertrand Perret; Anne Lespine
Journal:  Pharm Res       Date:  2006-09-15       Impact factor: 4.200

4.  The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy.

Authors:  Tara A Gomez; Kelley L Banfield; Dorothy M Trogler; Steven G Clarke
Journal:  Dev Biol       Date:  2006-11-21       Impact factor: 3.582

Review 5.  A biochemist's guide to Caenorhabditis elegans.

Authors:  Ann K Corsi
Journal:  Anal Biochem       Date:  2006-08-11       Impact factor: 3.365

6.  The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans.

Authors:  Olivier Zugasti; Jeena Rajan; Patricia E Kuwabara
Journal:  Genome Res       Date:  2005-10       Impact factor: 9.043

7.  Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration.

Authors:  Firas Bassissi; Anne Lespine; Michel Alvinerie
Journal:  Parasitol Res       Date:  2005-12-10       Impact factor: 2.289

8.  Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids.

Authors:  Adolfo Sánchez-Blanco; Alberto G Rodríguez-Matellán; Mariana Reis-Sobreiro; Beatriz Sáenz-Narciso; Juan Cabello; William A Mohler; Faustino Mollinedo
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 9.  The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles.

Authors:  Andrew D Chisholm; Suhong Xu
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2012-06-19       Impact factor: 5.814

10.  Multivesicular body formation requires OSBP-related proteins and cholesterol.

Authors:  Hiroyuki Kobuna; Takao Inoue; Machiko Shibata; Keiko Gengyo-Ando; Akitsugu Yamamoto; Shohei Mitani; Hiroyuki Arai
Journal:  PLoS Genet       Date:  2010-08-05       Impact factor: 5.917

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