An unusual side effect on the skin under high dose D-penicillamin treatment.

An unusual side effect on the skin after one year's high dosage (3,0 g/die) of D-Penicillamin-treatment is reported. The skin showed double-pin-sized vesicles and laceration after minor injuries. After reduction of the dosage to 1,8 g/die and bathing the hands three times/day for 2 minutes in 1% Tannin solution the skin lesions and wounds healed eventually.