John McGrath1, Darryl Eyles, Bryan Mowry, Robert Yolken, Stephen Buka. 1. Department of Psychiatry, Queensland Centre for Schizophrenia Research, University of Queensland, The Park Centre for Mental Health, Wacol Q4076, Australia. john_mcgrath@qcsr.uq.edu.au
Abstract
OBJECTIVE: Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD: Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected controls. For each case, we selected two controls matched on race, gender and date of birth of the offspring. RESULTS: There was no significant difference in third trimester maternal vitamin D in the entire sample (cases = 26, controls = 51). Within the subgroup of black individuals (n = 21), there was a trend level difference in the predicted direction. CONCLUSIONS: Maternal vitamin D does not operate as a continuous graded risk factor for schizophrenia, however, the results in the black subgroup raise the possibility that below a certain critical threshold, low levels of maternal vitamin D may be associated with an increased risk of schizophrenia.
OBJECTIVE: Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD: Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected controls. For each case, we selected two controls matched on race, gender and date of birth of the offspring. RESULTS: There was no significant difference in third trimester maternal vitamin D in the entire sample (cases = 26, controls = 51). Within the subgroup of black individuals (n = 21), there was a trend level difference in the predicted direction. CONCLUSIONS: Maternal vitamin D does not operate as a continuous graded risk factor for schizophrenia, however, the results in the black subgroup raise the possibility that below a certain critical threshold, low levels of maternal vitamin D may be associated with an increased risk of schizophrenia.
Authors: John J McGrath; Thomas H Burne; François Féron; Allan Mackay-Sim; Darryl W Eyles Journal: Schizophr Bull Date: 2010-09-10 Impact factor: 9.306
Authors: Maria Hedelin; Marie Löf; Marita Olsson; Tommy Lewander; Björn Nilsson; Christina M Hultman; Elisabete Weiderpass Journal: BMC Psychiatry Date: 2010-05-26 Impact factor: 3.630
Authors: Dennis K Kinney; Pamela Teixeira; Diane Hsu; Siena C Napoleon; David J Crowley; Andrea Miller; William Hyman; Emerald Huang Journal: Schizophr Bull Date: 2009-04-08 Impact factor: 9.306